Abstract
Background: Current HIV antiretroviral therapies potently suppress virus replication and prevent patients from progressing to AIDS but are unable to completely eliminate HIV due to the existence of dormant viral reservoirs which threaten to reemerge at anytime. Recently, genome-editing technologies that can recognize specific DNA sequences, including viral DNA, are being touted as promising tools for curing HIV, owing to their specificity, ease of use, and ability to be custom designed.
Conclusion: Here, we introduce several novel strategies aimed at eradicating HIV proviruses with state-of-the-art genomeediting technologies and discuss perspectives of these approaches for curing HIV.
Keywords: CRISPR/Cas9, genome editing, HIV, latency, provirus, TALENs, ZFNs.
Graphical Abstract
Current HIV Research
Title:Perspectives of Genome-Editing Technologies for HIV Therapy
Volume: 14 Issue: 1
Author(s): Hirotaka Ebina, Peter Gee and Yoshio Koyanagi
Affiliation:
Keywords: CRISPR/Cas9, genome editing, HIV, latency, provirus, TALENs, ZFNs.
Abstract: Background: Current HIV antiretroviral therapies potently suppress virus replication and prevent patients from progressing to AIDS but are unable to completely eliminate HIV due to the existence of dormant viral reservoirs which threaten to reemerge at anytime. Recently, genome-editing technologies that can recognize specific DNA sequences, including viral DNA, are being touted as promising tools for curing HIV, owing to their specificity, ease of use, and ability to be custom designed.
Conclusion: Here, we introduce several novel strategies aimed at eradicating HIV proviruses with state-of-the-art genomeediting technologies and discuss perspectives of these approaches for curing HIV.
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Cite this article as:
Ebina Hirotaka, Gee Peter and Koyanagi Yoshio, Perspectives of Genome-Editing Technologies for HIV Therapy, Current HIV Research 2016; 14 (1) . https://dx.doi.org/10.2174/1570162X13666150807105718
DOI https://dx.doi.org/10.2174/1570162X13666150807105718 |
Print ISSN 1570-162X |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4251 |
Call for Papers in Thematic Issues
HIV vaccine development
The development of a safe and effective vaccine that impedes HIV-1 transmission and/or limits the severity of infection remains a public health priority. The HIV-1/AIDS pandemic continues to have a disproportionate impact on vulnerable and under-served communities in the USA and globally. In the USA, minority communities that have relatively ...read more
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