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Current Pharmaceutical Design

Editor-in-Chief

ISSN (Print): 1381-6128
ISSN (Online): 1873-4286

Dendritic Cell Endothelium Interaction in Autoimmunity

Author(s): C. L. Schlichting, W. D. Schareck and M. Weis

Volume 10, Issue 2, 2004

Page: [171 - 181] Pages: 11

DOI: 10.2174/1381612043453397

Price: $65

Abstract

Monocyte derived dendritic cells play a central role in controlling immunity by activating naïve T lymphocytes. Monocytes can leave the blood stream by endothelial cell transmigration and differentiation into dendritic cells. A fundamental aspect of dendritic cell biology is their capacity to engulf tissue antigens and revers-migrate into lymph nodes. In lymph nodes dendritic cells can traffic to T-cell areas where they activate naïve T-cells. Throughout this review we are developing a model of in vivo activation of auto-reactive T-cells by activated dendritic cells.

Keywords: autoimmunity, dendritic cells, endothelium, endothelial cell, migration, inflammation


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