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Current Organic Synthesis


ISSN (Print): 1570-1794
ISSN (Online): 1875-6271

Natural Naphthoquinones with Great Importance in Medicinal Chemistry

Author(s): Fernando de Carvalho da Silva and Vitor Francisco Ferreira

Volume 13, Issue 3, 2016

Page: [334 - 371] Pages: 38

DOI: 10.2174/1570179412666150817220343

Price: $65


This review involves the chemistry and biochemistry of lapachol, β-lapachone and lawsone, examples of bioactive natural products that still being under biological evaluation and stimulated several research groups to prepare derivatives and analogues and test them against several anticancer, trypanocidal, antinflammatory, tuberculostatic, and antimalarial targets, as well as other parasitology targets related to important infectious diseases.

Keywords: β-lapachone, lapachol, lawsone, derivatives, biological activities, synthesis.

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