Abstract
The hedgehog (Hh) pathway is a developmental signaling pathway that is essential to the proper embryonic development of many vertebrate systems. Dysregulation of Hh signaling has been implicated as a causative factor in the development and progression of several forms of human cancer. As such, the development of small molecule inhibitors of Hh signaling as potential anti-cancer chemotherapeutics has been a major area of research interest in both academics and industry over the past ten years. Through these efforts, synthetic small molecules that target multiple components of the Hh pathway have been identified and advanced to preclinical or clinical development. The goal of this review is to provide an update on the current status of several synthetic small molecule Hh pathway inhibitors and explore the potential of several recently disclosed inhibitory scaffolds.
Keywords: Basal cell carcinoma, gli, hedgehog signaling, medulloblastoma, smoothened, synthetic small molecules.
Current Medicinal Chemistry
Title:Synthetic Small Molecule Inhibitors of Hh Signaling As Anti-Cancer Chemotherapeutics
Volume: 22 Issue: 35
Author(s): C.A. Maschinot, J.R. Pace and M.K. Hadden
Affiliation:
Keywords: Basal cell carcinoma, gli, hedgehog signaling, medulloblastoma, smoothened, synthetic small molecules.
Abstract: The hedgehog (Hh) pathway is a developmental signaling pathway that is essential to the proper embryonic development of many vertebrate systems. Dysregulation of Hh signaling has been implicated as a causative factor in the development and progression of several forms of human cancer. As such, the development of small molecule inhibitors of Hh signaling as potential anti-cancer chemotherapeutics has been a major area of research interest in both academics and industry over the past ten years. Through these efforts, synthetic small molecules that target multiple components of the Hh pathway have been identified and advanced to preclinical or clinical development. The goal of this review is to provide an update on the current status of several synthetic small molecule Hh pathway inhibitors and explore the potential of several recently disclosed inhibitory scaffolds.
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Cite this article as:
Maschinot C.A., Pace J.R. and Hadden M.K., Synthetic Small Molecule Inhibitors of Hh Signaling As Anti-Cancer Chemotherapeutics, Current Medicinal Chemistry 2015; 22 (35) . https://dx.doi.org/10.2174/0929867322666150827093904
DOI https://dx.doi.org/10.2174/0929867322666150827093904 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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