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Current Topics in Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 1568-0266
ISSN (Online): 1873-4294

Relationships Between Mitochondria and Neuroinflammation: Implications for Alzheimer’s Disease

Author(s): Heather M. Wilkins and Russell H. Swerdlow

Volume 16, Issue 8, 2016

Page: [849 - 857] Pages: 9

DOI: 10.2174/1568026615666150827095102

Price: $65

Abstract

Mitochondrial dysfunction and neuroinflammation occur in Alzheimer’s disease (AD). The causes of these pathologic lesions remain uncertain, but links between these phenomena are increasingly recognized. In this review, we discuss data that indicate mitochondria or mitochondrial components may contribute to neuroinflammation. While mitochondrial dysfunction could cause neuroinflammation, neuroinflammation could also cause mitochondrial dysfunction. However, based on the systemic nature of AD mitochondrial dysfunction as well as data from experiments we discuss, the former possibility is perhaps more likely. If correct, then manipulation of mitochondria, either directly or through manipulations of bioenergetic pathways, could prove effective in reducing metabolic dysfunction and neuroinflammation in AD patients. We also review some potential approaches through which such manipulations may be achieved.

Keywords: Alzheimer’s disease, Bioenergetics, Damage associated molecular pattern, Inflammation, Mitochondria.

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