Abstract
Cryptococcosis, an invasive fungal infection that affects both immunocompromised and immunocompetent individuals, has emerged as an important public health problem in Africa, Asia, and America. The limited number of antimycotic drugs available to treat this disease, their side effects and toxicity, and the emergence of resistant strains support the search for more effective and less toxic compounds. This review compiles examples of novel synthetic compounds, which could be used as templates for developing novel drugs for the treatment of Cryptococcus infections.
Keywords: Antifungal, azole, cryptococcosis, Cryptococcus, heterocycles, natural product derivatives, peptide, phospholipidic compounds.
Current Organic Synthesis
Title:Novel Synthetic Compounds as Potential Anticryptococcal Agents
Volume: 12 Issue: 6
Author(s): Soraya M. Z. M. D. Ferreira, Cleiton M. da Silva, Ângelo de Fátima and Rossimiriam P. Freitas
Affiliation:
Keywords: Antifungal, azole, cryptococcosis, Cryptococcus, heterocycles, natural product derivatives, peptide, phospholipidic compounds.
Abstract: Cryptococcosis, an invasive fungal infection that affects both immunocompromised and immunocompetent individuals, has emerged as an important public health problem in Africa, Asia, and America. The limited number of antimycotic drugs available to treat this disease, their side effects and toxicity, and the emergence of resistant strains support the search for more effective and less toxic compounds. This review compiles examples of novel synthetic compounds, which could be used as templates for developing novel drugs for the treatment of Cryptococcus infections.
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Ferreira M. Z. M. D. Soraya, da Silva M. Cleiton, Fátima de Ângelo and Freitas P. Rossimiriam, Novel Synthetic Compounds as Potential Anticryptococcal Agents, Current Organic Synthesis 2015; 12 (6) . https://dx.doi.org/10.2174/157017941206150828111041
DOI https://dx.doi.org/10.2174/157017941206150828111041 |
Print ISSN 1570-1794 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6271 |
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Exploring the Role of Chemical Graph Theory in Advancing Current Organic Synthesis
Organic synthesis is a fundamental discipline in chemistry, crucial for the creation of complex molecules with diverse applications in pharmaceuticals, materials science, and beyond. However, the process of designing efficient synthetic routes for target molecules remains challenging. Chemical graph theory, a branch of theoretical chemistry, offers powerful tools for understanding ...read more
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