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Current Topics in Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 1568-0266
ISSN (Online): 1873-4294

Therapeutic Approaches to Eradicate Latent HIV-1 in Resting CD4+ T Cells

Author(s): Nicolas Sluis-Cremer

Volume 16, Issue 10, 2016

Page: [1191 - 1197] Pages: 7

DOI: 10.2174/1568026615666150901114138

Price: $65

Abstract

While combination antiretroviral therapy (cART) can drive HIV-1 RNA levels to < 50 copies/mL in patient plasma, most infected individuals continue to harbor low-level persistent viremia. Latently infected resting CD4+ T cells are thought to constitute the major reservoir of HIV-1 persistence. In this reservoir, the integrated provirus remains transcriptionally silent as long as the host cell is in a resting state. On discontinuation of cART, these viruses can reactivate and lead to waves of de novo infection events. The prevailing hypothesis in the field is that molecules that reactivate latent HIV-1 infection will purge this reservoir by inducing transcription of the latent provirus, thereby causing cells to undergo apoptosis. This review article summarizes the results of all therapeutic approaches that have been clinically evaluated for their potential to reverse HIV latency.

Keywords: Cure, HIV-1, Latency, Latency reversing agents, Resting CD4+ T cells.

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