Abstract
Apoptosis is an important process in the development of the nervous system. Typically, ∼50% of the neurons apoptose during neurogenesis before the nervous system matures. However, recent paradigms implicate premature apoptosis and / or aberrations in the fine control of neuronal apoptosis in the pathogenesis of a variety of neurodegenerative disorders such as Alzheimers disease, Parkinsons disease, Huntingtons disease, amyotrophic lateral sclerosis, spinal muscular atrophy, stroke, brain trauma, spinal cord injury, and diabetic neuropathy. This review will focus on the current concepts salient to understanding the apoptosis death program, the mediators and control of cellular apoptosis, and the relationship between aberrant apoptosis and genesis of neurodegenerative disorders. The discussion will also highlight current advances in methodology, such as utilization of neuronal cell lines and mutant animal models, in investigations of neuronal apoptotic death. The knowledge of apoptosis mechanisms could underpin the basis for development of novel therapeutic strategies and treatment modalities that are directed at control of the neuronal apoptotic death program.
Keywords: neuronal apoptosis, apoptosis and neurodegeneration, mitochondrial apoptotic signaling, oxidative stress and apoptosis, apoptosis and cerebrovascular injury, cerebral ischemia/reperfusion
Current Neurovascular Research
Title: Apoptosis: A Key in Neurodegenerative Disorders
Volume: 1 Issue: 4
Author(s): Oleksandr Ekshyyan and Tak Yee Aw
Affiliation:
Keywords: neuronal apoptosis, apoptosis and neurodegeneration, mitochondrial apoptotic signaling, oxidative stress and apoptosis, apoptosis and cerebrovascular injury, cerebral ischemia/reperfusion
Abstract: Apoptosis is an important process in the development of the nervous system. Typically, ∼50% of the neurons apoptose during neurogenesis before the nervous system matures. However, recent paradigms implicate premature apoptosis and / or aberrations in the fine control of neuronal apoptosis in the pathogenesis of a variety of neurodegenerative disorders such as Alzheimers disease, Parkinsons disease, Huntingtons disease, amyotrophic lateral sclerosis, spinal muscular atrophy, stroke, brain trauma, spinal cord injury, and diabetic neuropathy. This review will focus on the current concepts salient to understanding the apoptosis death program, the mediators and control of cellular apoptosis, and the relationship between aberrant apoptosis and genesis of neurodegenerative disorders. The discussion will also highlight current advances in methodology, such as utilization of neuronal cell lines and mutant animal models, in investigations of neuronal apoptotic death. The knowledge of apoptosis mechanisms could underpin the basis for development of novel therapeutic strategies and treatment modalities that are directed at control of the neuronal apoptotic death program.
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Cite this article as:
Ekshyyan Oleksandr and Aw Yee Tak, Apoptosis: A Key in Neurodegenerative Disorders, Current Neurovascular Research 2004; 1 (4) . https://dx.doi.org/10.2174/1567202043362018
DOI https://dx.doi.org/10.2174/1567202043362018 |
Print ISSN 1567-2026 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5739 |
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