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Current Molecular Pharmacology


ISSN (Print): 1874-4672
ISSN (Online): 1874-4702

Review Article

Mesenchymal Stem Cells and Cell Therapy for Bone Repair

Author(s): Shihua Wang, Pengchao Xu, Xiaoxia Li, Xiaodong Su, Yunfei Chen, Li Wan, Linyuan Fan, Kan Yin, Yan Liu and Robert Chunhua Zhao

Volume 9, Issue 4, 2016

Page: [289 - 299] Pages: 11

DOI: 10.2174/1874467208666150928153758

Price: $65


Mesenchymal stem cells (MSCs) represent a new therapeutic paradigm for a number of diseases because they possess unique biological characteristics such as multipotency, immunomodulation and production of cytokines. Currently, 425 MSC based clinical trials have been conducted for at least 12 kinds of pathological conditions, with many completed trials demonstrating the safety and efficacy of MSCs. Here, we provide an overview of the clinical status of MSCs by searching the public clinical trials database Particularly, the role of MSCs in clinical trials to treat bone defects and injuries is highlighted.

Keywords: Bone defects, clinical transition, differentiation, immunomodulation, mesenchymal stem cells, secretome.

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