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Current Topics in Medicinal Chemistry


ISSN (Print): 1568-0266
ISSN (Online): 1873-4294

Methodological Issues and Possible Clinical Implications for Exhaled Breath Condensate pH in Asthma

Author(s): Andras Bikov and Ildiko Horvath

Volume 16, Issue 14, 2016

Page: [1550 - 1560] Pages: 11

DOI: 10.2174/1568026616666150930120421

Price: $65


Exhaled breath condensate (EBC) pH is a commonly studied biomarker which represents the acidity of the whole airway tract, including the lower and upper airways as well as oral cavity. Because neat, unprocessed EBC pH can be affected by environmental and end-tidal carbon dioxide, two further reproducible techniques have been developed to measure condensate acidity with several methodological, pathophysiological and environmental factors which may influence EBC pH. Airway acidification may contribute to various pathological features of asthma, therefore EBC pH may be a non-invasive, but unspecific clinical biomarker of this disorder. This review summarises the current knowledge on EBC pH in asthma focusing on methodological aspects and possible clinical applications.

Keywords: Airway acidity; Airway inflammation; Asthma; Breath test; Exhaled breath condensate; Exhaled breath condensate pH.

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