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Current Drug Safety


ISSN (Print): 1574-8863
ISSN (Online): 2212-3911

Biologic Therapy in Inflammatory and Immunomediated Skin Diseases: Safety Profile

Author(s): Giulia Ganzetti, Anna Campanati, E. Molinelli and A. Offidani

Volume 11, Issue 1, 2016

Page: [12 - 21] Pages: 10

DOI: 10.2174/1574886310666151014121732

Price: $65


Biologic treatments have modified the therapeutic armamentarium in the treatment of many dermatological and non- dermatological diseases and data on literature have widely focused on the efficacy and safety of TNF-alpha inhibitors in psoriasis.

Although the etiopathogenesis has not completely elucidated, inflammation appears the lait motif unifying the immune-pathogenesis of diverse skin disease, as atopic dermatitis, alopecia areata and hidradenitis suppurativa.

Actually, data on the off-label use of biologics in cutaneous immune-mediated inflammatory diseases are scarce and restricted to anecdotal cases and case series.

The present review aims to evidence the major off- label use of TNF-alpha inhibitors in dermatology.

Keywords: Inflammation, immuno-mediated disease, anti-TNF-alpha, off-label use.

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