Abstract
It has been over half a century since propranolol, the first beta-blocker, was developed for medical treatment. Since that time a large number of compounds from this group have been synthesised and many are now in clinical use. The structure, function, pharmacokinetics, and mechanism of beta-blockers have been established. The possibilities for their use in treating different conditions continue to evolve. Since the discovery of later generation beta-blockers, such as carvedilol and nebivolol, the search for new compounds continues, and may include known substances with betablocking properties which could extend their therapeutic potential.
Keywords: Activity, application, aryloxyaminopropanol derivatives, beta-blockers, structure.
Mini-Reviews in Medicinal Chemistry
Title:Beta-Blockers: Current State of Knowledge and Perspectives
Volume: 16 Issue: 1
Author(s): Magdalena Ogrodowczyk, Katarzyna Dettlaff and Anna Jelinska
Affiliation:
Keywords: Activity, application, aryloxyaminopropanol derivatives, beta-blockers, structure.
Abstract: It has been over half a century since propranolol, the first beta-blocker, was developed for medical treatment. Since that time a large number of compounds from this group have been synthesised and many are now in clinical use. The structure, function, pharmacokinetics, and mechanism of beta-blockers have been established. The possibilities for their use in treating different conditions continue to evolve. Since the discovery of later generation beta-blockers, such as carvedilol and nebivolol, the search for new compounds continues, and may include known substances with betablocking properties which could extend their therapeutic potential.
Export Options
About this article
Cite this article as:
Ogrodowczyk Magdalena, Dettlaff Katarzyna and Jelinska Anna, Beta-Blockers: Current State of Knowledge and Perspectives, Mini-Reviews in Medicinal Chemistry 2016; 16 (1) . https://dx.doi.org/10.2174/1389557515666151016125948
DOI https://dx.doi.org/10.2174/1389557515666151016125948 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
Call for Papers in Thematic Issues
Bioprospecting of Natural Products as Sources of New Multitarget Therapies
According to the Convention on Biological Diversity, bioprospecting is the exploration of biodiversity and indigenous knowledge to develop commercially valuable products for pharmaceutical and other applications. Bioprospecting involves searching for useful organic compounds in plants, fungi, marine organisms, and microorganisms. Natural products traditionally constituted the primary source of more than ...read more
Computational Frontiers in Medicinal Chemistry
The thematic issue "Computational Frontiers in Medicinal Chemistry" provides a robust platform for delving into state-of-the-art computational methodologies and technologies that significantly propel advancements in medicinal chemistry. This edition seeks to amalgamate top-tier reviews spotlighting the latest trends and breakthroughs in the fusion of computational approaches, including artificial intelligence (AI) ...read more
Mitochondria as a Therapeutic Target in Metabolic Disorders
Mitochondria are the primary site of adenosine triphosphate (ATP) production in mammalian cells. Moreover, these organelles are an important source of reactive oxygen and nitrogen species in virtually any nucleated cell type. The modulation of a myriad of cellular signaling pathways depends on the mitochondrial physiology. Mitochondrial dysfunction is observed ...read more
Natural Products and Dietary Supplements in Alleviation of Metabolic, Cardiovascular, and Neurological Disorders
Metabolic disorders like diabetes, obesity, inflammation, oxidative stress, cancer etc, cardiovascular disorders like angina, myocardial infarction, congestive heart failure etc as well as neurological disorders like Alzheimer?s, Parkinson?s, Epilepsy, Depression, etc are the global burden. They covered the major segment of the diseases and disorders from which the human community ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
The Effects of Caffeine on the Cholinergic System
Mini-Reviews in Medicinal Chemistry Anderson-Fabry Disease in Children
Current Pharmaceutical Design Safety of Nanoparticles in Medicine
Current Drug Targets Assessing Drugs for their Cardio-Toxicity
Letters in Drug Design & Discovery Modulation of Inflammatory Response Improves Myocardial Infarct Healing in Rats
Current Pharmaceutical Design Chronic Complications of Diabetes Mellitus: A Mini Review
Current Diabetes Reviews Sodium Channel Inhibitor Drug Discovery Using Automated High Throughput Electrophysiology Platforms
Combinatorial Chemistry & High Throughput Screening Pathophysiological Insights into Atrial Fibrillation Following Cardiac Surgery: Implications for Current Pharmaceutical Design
Current Pharmaceutical Design Tetrazole Derivatives as Promising Anticancer Agents
Anti-Cancer Agents in Medicinal Chemistry Editorial (Thematic Issue: Recent Advances in Management of Myocarditis)
Current Pharmaceutical Design L-Type Voltage-Dependent Calcium Channels As Therapeutic Targets for Neurodegenerative Diseases
Current Medicinal Chemistry The Prevention and Treatment of Delirium in Elderly Patients Following Hip Fracture Surgery
Recent Patents on CNS Drug Discovery (Discontinued) Recent Patents on Accuracy of Blood Pressure Measurement
Recent Patents on Biomedical Engineering (Discontinued) The Measurement of the QT Interval
Current Cardiology Reviews Early Detection of Life-threatening Cardiac Arrhythmias Using Deep Learning Techniques
Current Signal Transduction Therapy Editorial [Hot Topic: The Adenosinergic System - From Physiology to Pathology and Therapeutics (Guest Editors: A. Rees and J. Ham)]
Immunology, Endocrine & Metabolic Agents in Medicinal Chemistry (Discontinued) A Palliative Care Approach to the Advanced Heart Failure Patient
Current Cardiology Reviews Novel Approaches Towards Designing of Isoform-Selective Inhibitors Against Class II Histone Deacetylases: The Acute Requirement for Targetted Anticancer Therapy
Current Topics in Medicinal Chemistry Inflammatory Arthritis and Heart Disease
Current Pharmaceutical Design Obesity Paradox in Atrial Fibrillation and its Relation with the New Oral Anticoagulants
Current Cardiology Reviews