摘要
背景:颅内出血的特征在于血管破裂和随后的血肿扩张。 它是最不可治疗的中风亚型,导致比缺血性中风更高的发病率和死亡率。 近期研究观察到脑内出血患者血浆纤维蛋白原水平低于正常水平。 此外,在其他严重出血的情况下,血浆纤维蛋白原水平已被确定为预后指标。 目前脑出血的临床治疗包括辅助治疗和可能的手术撤离。 然而,颅内出血的可能治疗靶点是纤维蛋白原。 在血肿扩张的颅内出血期间,纤维蛋白原水平迅速消耗,因此需要更换。 维持高水平的纤维蛋白原可以促进凝血快速和血肿扩张减少。 目的:在本综述中,我们检查纤维蛋白原在颅内出血中的作用,并评估使用纤维蛋白原替代疗法维持正常水平的这种关键止血蛋白。 讨论优点和缺点,并对颅内出血最合适的纤维蛋白原替代疗法做出意见。 结论:纤维蛋白原浓缩物似乎是提升血浆纤维蛋白原治疗血肿扩大的颅内出血最合适的治疗方法。
关键词: 纤维蛋白原,纤维蛋白原浓缩物,纤维蛋白原冷冻沉淀物,脑内出血,蛛网膜下腔出血,生发基质出血。
Current Drug Targets
Title:Maintaining Plasma Fibrinogen Levels and Fibrinogen Replacement Therapies for Treatment of Intracranial Hemorrhage
Volume: 18 Issue: 12
关键词: 纤维蛋白原,纤维蛋白原浓缩物,纤维蛋白原冷冻沉淀物,脑内出血,蛛网膜下腔出血,生发基质出血。
摘要: Background: Intracranial hemorrhage is characterized by the blood vessel rupture and subsequent hematoma expansion. It is the least treatable stroke subtype, resulting in higher morbidity and mortality per incidence than ischemic stroke. Recent studies have observed lower than normal levels of plasma fibrinogen in patients of intracerebral hemorrhage. Furthermore, in other cases of severe hemorrhage, plasma fibrinogen levels have been identified as an indicator of prognosis. Current clinical management of cerebral hemorrhage includes adjunctive therapies and possible surgical evacuation. However, a possible therapeutic target for intracranial hemorrhage is fibrinogen. During intracranial hemorrhage with hematoma expansion, fibrinogen levels are rapidly depleted and thus are in need of replacement. Maintaining high levels of fibrinogen can promote rapid clotting and reduction of hematoma expansion.
Objectives: Within this review, we examine the role of fibrinogen in intracranial hemorrhage and evaluate the use of fibrinogen replacement therapies for maintaining normal levels of this key hemostatic protein. The pros and cons are discussed and an opinion of the most appropriate fibrinogen replacement therapy for intracranial hemorrhage is made. Conclusion: It is concluded that fibrinogen concentrate seems to be the most suitable therapy for elevating plasma fibrinogen for the treatment of intracranial hemorrhage with hematoma expansion.Export Options
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Cite this article as:
Maintaining Plasma Fibrinogen Levels and Fibrinogen Replacement Therapies for Treatment of Intracranial Hemorrhage, Current Drug Targets 2017; 18 (12) . https://dx.doi.org/10.2174/1389450117666151209123857
DOI https://dx.doi.org/10.2174/1389450117666151209123857 |
Print ISSN 1389-4501 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5592 |
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