摘要
新兴的免疫治疗靶向检查点和肿瘤相关抗原引导了重要的临床进展以及提供给患有前列腺癌(PCa),膀胱癌(BC),特别是肾细胞癌(RCC)的患者一种新武器。在当前的治疗方案或泌尿生殖肿瘤中,以排序或组合的方法来整合这些因子,这取决于对免疫系统以及癌症相关的免疫抑制机制促癌活性的更为深刻的理解。在这方面,中性粒细胞,T、B淋巴细胞以及肿瘤相关的巨噬细胞(TAMs)与发病机制,泌尿系统肿瘤耐药性的发生和发展有牵连。这篇文章是一个关于免疫细胞作用最新见解的综述。
关键词: 泌尿生殖系统肿瘤;免疫治疗;淋巴细胞;巨噬细胞;中性粒细胞。
Current Drug Targets
Title:An Overview of Emerging Immunotargets of Genitourinary Tumors
Volume: 17 Issue: 7
Author(s): Rodolfo Montironi, Matteo Santoni, Liang Cheng, Antonio Lopez-Beltran, Francesco Massari, Marc R. Matrana, Holger Moch and Marina Scarpelli
Affiliation:
关键词: 泌尿生殖系统肿瘤;免疫治疗;淋巴细胞;巨噬细胞;中性粒细胞。
摘要: Emerging immunotherapies targeting immune checkpoints and tumor associated antigens are leading to important clinical advances and providing a new weapon in patients with prostate (PCa) and bladder cancer (BC) and, in particular, with renal cell carcinoma (RCC). The possibility to integrate these agents in the current therapeutic scenario or genitourinary tumors, both in sequential or combined approaches, relies on a more profound comprehension of the protumorigenic activity of the immune system and of the mechanisms of cancer-related immunosuppression. In this regards, neutrophils, T and B lymphocytes and tumor-associated macrophages (TAMs) are implicated in the pathogenesis, progression and development of drug resistance in genitourinary tumors. This review is an overview on the recent insights concerning the role of immune cells in this context.
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Rodolfo Montironi, Matteo Santoni, Liang Cheng, Antonio Lopez-Beltran, Francesco Massari, Marc R. Matrana, Holger Moch and Marina Scarpelli , An Overview of Emerging Immunotargets of Genitourinary Tumors, Current Drug Targets 2016; 17 (7) . https://dx.doi.org/10.2174/1389450117666151209144649
DOI https://dx.doi.org/10.2174/1389450117666151209144649 |
Print ISSN 1389-4501 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5592 |
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