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Current Pharmaceutical Design


ISSN (Print): 1381-6128
ISSN (Online): 1873-4286

Benzofuran Small Molecules as Potential Inhibitors of Human Protein Kinases. A Review

Author(s): Halina Kwiecień, Agata Goszczyńska and Paulina Rokosz

Volume 22, Issue 7, 2016

Page: [879 - 894] Pages: 16

DOI: 10.2174/1381612822666151209152457

Price: $65


Kinases are known to regulate the majority of human cellular processes such as communication, division, metabolism, survival and apoptosis therefore they can be promising targets in cancer diseases, viral infection and in other disorders. Small molecules acting as selective human protein kinase inhibitors are very attractive pharmacological targets. This review presents a number of examples of biologically active natural and synthetic benzo[b]furans and their derivatives, such as benzo[b]furan-2- and 3-ones, benzo[b]furan-2- and 3-carboxylic acids, as well as benzo[c]furans as potential inhibitors of various human protein kinases. The pathways of function and implication of the inhibitors in cancer and other diseases are discussed.

Keywords: Kinase, inhibitor, anti-cancer, benzo[b]furan, benzo[c]furan, biological activity.

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