Abstract
Herein, we present an overview on the current status of the characterization techniques and methodologies used to study the physicochemical descriptors that influence the final clinical performance of a given nanomedicine. The described techniques were selected based on their suitability to operate under relevant “native” conditions that mimic the physiological environment. Special emphasis is placed on those techniques that hold a greater potential to unravel dynamic, structural, and compositional features of soft organic nanomedicines relevant to the ability to bypass biological barriers, and hence allow for the rational design of drug delivery platforms with improved biological output.
Keywords: Nanomedicines, drug delivery systems, biological barriers, characterization techniques, polymer therapeutics.
Current Pharmaceutical Design
Title:Relevant Physicochemical Descriptors of “Soft Nanomedicines” to Bypass Biological Barriers
Volume: 22 Issue: 9
Author(s): Amaya Nino-Pariente, Vicent J. Nebot and Maria J. Vicent
Affiliation:
Keywords: Nanomedicines, drug delivery systems, biological barriers, characterization techniques, polymer therapeutics.
Abstract: Herein, we present an overview on the current status of the characterization techniques and methodologies used to study the physicochemical descriptors that influence the final clinical performance of a given nanomedicine. The described techniques were selected based on their suitability to operate under relevant “native” conditions that mimic the physiological environment. Special emphasis is placed on those techniques that hold a greater potential to unravel dynamic, structural, and compositional features of soft organic nanomedicines relevant to the ability to bypass biological barriers, and hence allow for the rational design of drug delivery platforms with improved biological output.
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Cite this article as:
Nino-Pariente Amaya, Nebot J. Vicent and Vicent J. Maria, Relevant Physicochemical Descriptors of “Soft Nanomedicines” to Bypass Biological Barriers, Current Pharmaceutical Design 2016; 22 (9) . https://dx.doi.org/10.2174/1381612822666151216152143
DOI https://dx.doi.org/10.2174/1381612822666151216152143 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
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