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Current Pharmaceutical Biotechnology

Editor-in-Chief

ISSN (Print): 1389-2010
ISSN (Online): 1873-4316

Cytotoxic Nitrobenzoyloxy-substituted Sesquiterpenes from Spongederived Endozoic Fungus Aspergillus insulicola MD10-2

Author(s): Hong-Ying Zhao, Ramasamy Anbuchezhian, Wei Sun, Chang-Lun Shao, Feng-Li Zhang, Ying Yin, Zhi-Sheng Yu, Zhi-Yong Li and Chang-Yun Wang

Volume 17, Issue 3, 2016

Page: [271 - 274] Pages: 4

DOI: 10.2174/1389201017666151223123424

Price: $65

Abstract

The emergence of drug resistance and spread of new infectious diseases necessitated the development of novel antibiotics. Marine sponge-associated fungi represent a reservoir of novel molecules with diverse biological potentials. In this study, we isolated five nitrobenzoyloxy-substituted sesquiterpenes 1-5 from the culture mycelia of an endozoic fungus Aspergillus insulicola MD10-2, obtained from the South China Sea sponge Cinachyrella australiensis. Compound 2 showed cytotoxicity against human lung cancer cell line H-460 with an IC50 value of 6.9 µM. Cytotoxicity of the acetylated derivatives (2a and 2b) of compound 2 decreased markedly, suggesting that the hydroxyl group contributed to the cytotoxic activity. Compound 5 was inactive against H-460, which implied the double bond at C-7 had an effect on cytotoxic activity as well.

Keywords: Marine fungus, Aspergillus insulicola, sponge, sesquiterpene, lung cancer, cytotoxic activity.


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