Abstract
The relative non-specificity of the first generation MR contrast agents has meant that a new approach to their design is required. This review focuses on a new class of more specific or functional agents. These are the so-called “activated”, “smart” or “responsive” contrast agents. The relaxivity of an activated contrast agent is responsive to (or can be modulated by) a particular in vivo stimulus such as a change in biological environment or activity. More specifically, a “switching on” of contrast in response to an event such as a change in physiological pH, metal ion concentration, enzyme activity or partial pressure of oxygen is sought. The current generation of activated MR contrast agents is discussed herein.
Keywords: oxygen, MR Contrast Agents
Current Pharmaceutical Biotechnology
Title: Activated MR Contrast Agents
Volume: 5 Issue: 6
Author(s): Mark P. Lowe
Affiliation:
Keywords: oxygen, MR Contrast Agents
Abstract: The relative non-specificity of the first generation MR contrast agents has meant that a new approach to their design is required. This review focuses on a new class of more specific or functional agents. These are the so-called “activated”, “smart” or “responsive” contrast agents. The relaxivity of an activated contrast agent is responsive to (or can be modulated by) a particular in vivo stimulus such as a change in biological environment or activity. More specifically, a “switching on” of contrast in response to an event such as a change in physiological pH, metal ion concentration, enzyme activity or partial pressure of oxygen is sought. The current generation of activated MR contrast agents is discussed herein.
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Cite this article as:
Lowe P. Mark, Activated MR Contrast Agents, Current Pharmaceutical Biotechnology 2004; 5 (6) . https://dx.doi.org/10.2174/1389201043376562
DOI https://dx.doi.org/10.2174/1389201043376562 |
Print ISSN 1389-2010 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4316 |
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