摘要
嗜酸性粒细胞是居住在血液和组织包括肺、乳腺、胃肠道和生殖系统中的粒细胞白细胞。在健康个体中,嗜酸性粒细胞增多症是罕见的。然而,它与过敏,寄生虫感染和一些炎症状态有关。在癌症中,嗜酸性粒细胞也被观测,包括结肠癌,乳腺癌,卵巢癌,宫颈癌,口腔癌,霍奇金淋巴瘤和前列腺癌等。嗜酸性粒细胞导致有利或不利的预后仍然存在争议,取决于许多因素,包括癌症的类型增加。嗜酸性粒细胞浸润对霍奇金淋巴瘤是不利的,相反地,它还与结直肠癌预后良好,乳腺癌和前列腺癌有关。嗜酸性粒细胞分泌多种细胞因子和因素,其中包括嗜酸性粒细胞阳离子蛋白,嗜酸性粒细胞神经毒素,过氧化物酶和主要碱性蛋白,它们具有抗肿瘤作用或刺激肿瘤的进展。在此,我们将讨论嗜酸粒细胞在肿瘤免疫中的作用机制,从而解释他们在肿瘤发生时的作用差异。
关键词: 癌;嗜酸性粒细胞;嗜酸性粒细胞癌;预后。
Current Medicinal Chemistry
Title:Eosinophils in Cancer: Favourable or Unfavourable?
Volume: 23 Issue: 7
Author(s): Samy Sakkal, Sarah Miller, Vasso Apostolopoulos, Kulmira Nurgali
Affiliation:
关键词: 癌;嗜酸性粒细胞;嗜酸性粒细胞癌;预后。
摘要: Eosinophils are granulocytic leukocytes residing in blood and tissues in the lung, breast, gastrointestinal and reproductive systems. Eosinophilia is uncommon in healthy individuals, however, it is associated with allergies, helminth infections and some inflammatory states. Eosinophilia has also been observed in cancer, including colorectal, breast, ovarian, cervical, oral squamous, Hodgkin’s lymphoma and prostate cancer. Whether an increase in eosinophils leading to a favourable or unfavourable prognosis still remains controversial and depends on many factors including the type of cancer. Eosinophil infiltration is considered unfavourable in Hodgkin’s lymphoma, conversely it has also been linked to a favourable prognosis in colorectal, breast and prostate cancers. Eosinophils secrete a variety of cytokines and factors including eosinophil cationic protein, eosinophil-derived neurotoxin, peroxidase and major basic protein which have either anti-tumor effects or stimulate tumor progression. Herein, we discuss the role of eosinophils in tumor immunity and propose mechanisms accounting for their functional differences in tumorigenesis.
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Cite this article as:
Samy Sakkal, Sarah Miller, Vasso Apostolopoulos, Kulmira Nurgali , Eosinophils in Cancer: Favourable or Unfavourable?, Current Medicinal Chemistry 2016; 23 (7) . https://dx.doi.org/10.2174/0929867323666160119094313
DOI https://dx.doi.org/10.2174/0929867323666160119094313 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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