Generic placeholder image

CNS & Neurological Disorders - Drug Targets


ISSN (Print): 1871-5273
ISSN (Online): 1996-3181

Linkage of Stress with Neuromuscular Disorders

Author(s): Ghulam M. Ashraf, Ashraf Ali, Shams Tabrez, Syed Kashif Zaidi, Shazi Shakil, Mohammad Z. Alam, Mohammad Rehan and Gjumrakch Aliev

Volume 15, Issue 3, 2016

Page: [321 - 328] Pages: 8

DOI: 10.2174/1871527315666160202124900

Price: $65


Aging is associated with a progressive loss of muscle strength and mass, and a decline in neurophysiologic functions, which are characteristic features of neuromuscular disorders (NMDs). Understanding aging induced neuromuscular junction (NMJ) dysfunction is very crucial to understand the mechanism underlying NMDs. Morphological and physiological changes result in remodelling of the motor unit and a decline in the number of motor neuron muscle fibres. These alterations lead to excitation–contraction uncoupling and a loss of communication between the neuromuscular system, causing a decline in skeletal muscle strength and muscle mass. Understanding the molecular basis of NMJ dysfunction is essential in search for new treatment options. Besides structural and molecular studies, search for animal models to establish connection between brain and muscle is needed. Among various factors it has been observed that stress is one of the leading causes of NMDs. In the present review, we aim to explore various factors linking stress and NMDs neuromuscular disorders which gets aggravated by aging, with a special emphasis on mitochondrial connection. This in turn will help us gain new insights in the treatment of NMDs by aiding in improved symptoms, increased mobility and prolonged life.

Keywords: Stress, neuromuscular disorders, neuromuscular junction, fibromyalgia syndrome, oxidative stress.

Rights & Permissions Print Cite
© 2024 Bentham Science Publishers | Privacy Policy