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Current Genomics


ISSN (Print): 1389-2029
ISSN (Online): 1875-5488

Transport of Calcium Ions into Mitochondria

Author(s): Zhaolong Xu, Dayong Zhang, Xiaolan He, Yihong Huang and Hongbo Shao

Volume 17, Issue 3, 2016

Page: [215 - 219] Pages: 5

DOI: 10.2174/1389202917666160202215748

Price: $65


To uptake calcium ions of mitochondria is of significant functional connotation for cells, because calcium ions in mitochondria are involved in energy production, regulatory signals transfer, and mitochondrial permeability transition pore opening and even programmed cell death of apoptosis, further playing more roles in plant productivity and quality. Cytoplasmic calcium ions access into outer mitochondrial membrane (OMM) from voltage dependent anion-selective channel (VDAC) and were absorbed into inner mitochondrial membrane (IMM) by mitochondrial calcium uniporter (MCU), rapid mitochondrial calcium uptake (RaM) or mitochondrial ryanodine receptor (mRyR). Although both mitochondria and the mechanisms of calcium transport have been extensively studied, but there are still long-standing or even new challenges. Here we review the history and recent discoveries of the mitochondria calcium ions channel complex involved calcium assimilation, and discuss the role of calcium ions into mitochondria.

Keywords: Mitochondria, Channels, Calcium ions uptake, Uniporter.

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