Abstract
In the near future, a number of molecules employed in insect pest control may lose their efficacy. Pesticide resistance is an increasing problem of public health importance, and more environmental-friendly control approaches against arthropod pests of medical and veterinary relevance are urgently needed. The seed oil of neem, Azadirachta indica (Meliaceae), contains more than 100 biologically active compounds. Many formulations derived from them showed biotoxicity, antifeedancy and repellent activity against several important mosquito species, including malaria, dengue, zika and filariasis vectors. In this review, we focus on the effectiveness of neem-borne mosquitocides, with the goal to develop an ideal mosquitocide, that should be effective, eco-friendly and cheap, being preferentially derived from botanical by-products (e.g. neem cake) easily produced by countries with limited industrial facilities.
Keywords: Azadirachtin A, biosafety, dengue, filariasis, limonoids, malaria, neem cake, nimbin, salannin.
Current Organic Chemistry
Title:Neem-Borne Molecules as Eco-Friendly Control Tools Against Mosquito Vectors of Economic Importance
Volume: 20 Issue: 25
Author(s): Marcello Nicoletti, Kadarkarai Murugan, Angelo Canale and Giovanni Benelli
Affiliation:
Keywords: Azadirachtin A, biosafety, dengue, filariasis, limonoids, malaria, neem cake, nimbin, salannin.
Abstract: In the near future, a number of molecules employed in insect pest control may lose their efficacy. Pesticide resistance is an increasing problem of public health importance, and more environmental-friendly control approaches against arthropod pests of medical and veterinary relevance are urgently needed. The seed oil of neem, Azadirachta indica (Meliaceae), contains more than 100 biologically active compounds. Many formulations derived from them showed biotoxicity, antifeedancy and repellent activity against several important mosquito species, including malaria, dengue, zika and filariasis vectors. In this review, we focus on the effectiveness of neem-borne mosquitocides, with the goal to develop an ideal mosquitocide, that should be effective, eco-friendly and cheap, being preferentially derived from botanical by-products (e.g. neem cake) easily produced by countries with limited industrial facilities.
Export Options
About this article
Cite this article as:
Nicoletti Marcello, Murugan Kadarkarai, Canale Angelo and Benelli Giovanni, Neem-Borne Molecules as Eco-Friendly Control Tools Against Mosquito Vectors of Economic Importance, Current Organic Chemistry 2016; 20 (25) . https://dx.doi.org/10.2174/1385272820666160218233923
DOI https://dx.doi.org/10.2174/1385272820666160218233923 |
Print ISSN 1385-2728 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5348 |
Call for Papers in Thematic Issues
Advances of Heterocyclic Chemistry with Pesticide Activity
Global food safety and security will continue to be a global concern for the next 50 years and beyond. Plant diseases have had a significant impact on food safety and security throughout the entire food chain, from primary production to consumption. While conventional chemical pesticides have been traditionally used for ...read more
Calculation design of covalent/metal organic framework based catalysts
This research area combines theoretical computation and screening with machine learning for the design of covalent/metal organic framework-based catalysts, bridging the disciplines of organic chemistry, physical chemistry, computational chemistry, materials science, and machine learning. It covers several critical aspects: designing and synthesizing organic catalysts for improved performance, applying computational methods ...read more
Carbohydrates conversion in biofuels and bioproducts
Biomass pretreatment, hydrolysis, and saccharification of carbohydrates, and sugars bioconversion in biofuels and bioproducts within a biorefinery framework. Carbohydrates derived from woody biomass, agricultural wastes, algae, sewage sludge, or any other lignocellulosic feedstock are included in this issue. Simulation, techno-economic analysis, and life cycle analysis of a biorefinery process are ...read more
Catalytic C-H bond activation as a tool for functionalization of heterocycles
The major topic is the functionalization of heterocycles through catalyzed C-H bond activation. The strategies based on C-H activation not only provide straightforward formation of C-C or C-X bonds but, more importantly, allow for the avoidance of pre-functionalization of one or two of the cross-coupling partners. The beneficial impact of ...read more
Related Journals
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Superparamagnetic Iron Oxide Nanoparticles (SPIONs): Synthesis and Surface Modification Techniques for use with MRI and Other Biomedical Applications
Current Pharmaceutical Design Iron Chelating Strategies in Systemic Metal Overload, Neurodegeneration and Cancer
Current Medicinal Chemistry Toward the Design of MR Agents for Imaging β-Cell Function
Current Medicinal Chemistry - Immunology, Endocrine & Metabolic Agents Entry of Oximes into the Brain: A Review
Current Medicinal Chemistry Biological Implications of Oxidation and Unidirectional Chiral Inversion of D-amino Acids
Current Drug Metabolism Hormone Replacement Therapy and Stroke
Current Vascular Pharmacology Lysosomal Storage Diseases and the Blood-Brain Barrier
Current Pharmaceutical Design Recent Advances in Copper Radiopharmaceuticals
Current Radiopharmaceuticals Interrelationships Between Cyclooxygenases and Aromatase: Unraveling the Relevance of Cyclooxygenase Inhibitors in Breast Cancer
Anti-Cancer Agents in Medicinal Chemistry Vascular Endothelial Growth Factor and Vascular Endothelial Growth Factor Receptor Inhibitors as Anti-Angiogenic Agents in Cancer Therapy
Recent Patents on Anti-Cancer Drug Discovery The Discovery and Potential of N-Sulfonylated Dipeptide VLA-4 Antagonists
Current Topics in Medicinal Chemistry Induction of CYP1A1. The AhR / DRE Paradigm Transcription, Receptor Regulation, and Expanding Biological Roles
Current Drug Metabolism The First Years of Linezolid Experience in Clinical Practice: A Balance and Future Implications
Anti-Infective Agents in Medicinal Chemistry Pro-Inflammatory Mechanisms in Diabetic Neuropathy: Focus on the Nuclear Factor Kappa B Pathway
Current Drug Targets Tetracyclic Triterpenoids in Herbal Medicines and their Activities in Diabetes and its Complications
Current Topics in Medicinal Chemistry Isoform-Selective PI3K Inhibitors for Various Diseases
Current Topics in Medicinal Chemistry Thrombophilia and Female Sex Hormones
Current Women`s Health Reviews The Role of Fatty Acids in the Regulation of Cerebral Vascular Function and Neuroprotection in Ischemia
CNS & Neurological Disorders - Drug Targets Heterocyclic Curcumin Derivatives of Pharmacological Interest: Recent Progress
Current Topics in Medicinal Chemistry Management of Inflammation by Natural Polyphenols: A Comprehensive Mechanistic Update
Current Medicinal Chemistry