锂和神经退行性疾病风险之间的关联的总体研究

Title:Population Studies of Association Between Lithium and Risk of Neurodegenerative Disorders

Volume: 13 Issue: 8

Author(s): Markus Donix and Michael Bauer

Affiliation:

关键词: 阿尔茨海默病、痴呆、锂、神经保护、人口研究，降低风险。

摘要: Background: Lithium shows neuroprotective and neurotrophic effects in vitro and in vivo. Due to its involvement in hippocampal neurogenesis and the interaction with beta-amyloid and neurofibrillary tangle metabolism it has been hypothesized that lithium could have the potential to influence the development of dementia. Method: Using the PubMed database and cross-reference search strategies our aim was to specifically identify population (cohort or case-control) studies investigating the association between lithium and dementia. Results: Data from large cohort studies suggest an association between lithium treatment and dementia risk reduction or reduced dementia severity. Studies with smaller sample sizes yield more variable findings. Conclusions: Lithium may reduce the risk of dementia among middle-aged and older people. Beneficial lithium effects are possibly limited to specific types of neurodegenerative processes.

Cite this article as:

Markus Donix and Michael Bauer , Population Studies of Association Between Lithium and Risk of Neurodegenerative Disorders, Current Alzheimer Research 2016; 13 (8) . https://dx.doi.org/10.2174/1567205013666160219112957