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Current Medicinal Chemistry


ISSN (Print): 0929-8673
ISSN (Online): 1875-533X

Food Proteins as Source of Opioid Peptides-A Review

Author(s): Swati Garg, Kulmira Nurgali and Vijay Kumar Mishra

Volume 23, Issue 9, 2016

Page: [893 - 910] Pages: 18

DOI: 10.2174/0929867323666160219115226

open access plus


Traditional opioids, mainly alkaloids, have been used in the clinical management of pain for a number of years but are often associated with numerous side-effects including sedation, dizziness, physical dependence, tolerance, addiction, nausea, vomiting, constipation and respiratory depression which prevent their effective use. Opioid peptides derived from food provide significant advantages as safe and natural alternative due to the possibility of their production using animal and plant proteins as well as comparatively less side-effects. This review aims to discuss the current literature on food-derived opioid peptides focusing on their production, methods of detection, isolation and purification. The need for screening more dietary proteins as a source of novel opioid peptides is emphasized in order to fully understand their potential in pain management either as a drug or as part of diet complementing therapeutic prescription.

Keywords: Opioids, peptide, opioid-receptors, casomorphins, exorphin, fermentation.

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