摘要
循环肿瘤细胞(CTCs)有明显的诊断潜力因为可以反映多种癌症的存在和复发。然而,这种潜力仍然是有限的,缺乏强大的和可得到的隔离技术。替代隔离可能是他们的直接检测,其中包括其他外周血细胞,这将需要标记物,使他们可以区分于一个非常高的背景信号。审查评估的Hox基因的潜在作用,一系列的同源域包括在胚胎发育和肿瘤发生中的关键作用域,作为独特的和可能的疾病和特定的标记。
关键词: 循环肿瘤细胞,Hox基因,生物标志物。
Current Molecular Medicine
Title:HOX Genes as Potential Markers of Circulating Tumour Cells
Volume: 16 Issue: 4
Author(s): R. Morgan, M. El-Tanani
Affiliation:
关键词: 循环肿瘤细胞,Hox基因,生物标志物。
摘要: Circulating tumour cells (CTCs) have significant diagnostic potential as they can reflect both the presence and recurrence of a wide range of cancers. However, this potential continues to be limited by the lack of robust and accessible isolation technologies. An alternative to isolation might be their direct detection amongst other peripheral blood cells, although this would require markers that allow them to be distinguished from an exceptionally high background signal. This review assesses the potential role of HOX genes, a family of homeodomain containing transcription factors with key roles in both embryonic development and oncogenesis, as unique and possibly disease specific markers of CTCs.
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Cite this article as:
R. Morgan, M. El-Tanani , HOX Genes as Potential Markers of Circulating Tumour Cells, Current Molecular Medicine 2016; 16 (4) . https://dx.doi.org/10.2174/1566524016666160316145715
DOI https://dx.doi.org/10.2174/1566524016666160316145715 |
Print ISSN 1566-5240 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5666 |
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