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Current Genomics


ISSN (Print): 1389-2029
ISSN (Online): 1875-5488

Genetic Abnormalities in Prostate Cancer

Author(s): Sanjeev Shukla, Gregory T. MacLennan, Susan R. Marengo, Allen D. Seftel, Martin I. Resnick and Sanjay Gupta

Volume 5, Issue 1, 2004

Page: [67 - 83] Pages: 17

DOI: 10.2174/1389202043490014

Price: $65


Molecular genetic mechanisms show diversity during prostate carcinogenesis due to extensive tumor heterogeneity and gene complexity. Understanding the molecular mechanisms involved in initiation and progression of prostate cancer will lead to the development of strategies for early detection, prevention and therapeutic intervention. This review focuses on inheritable and sporadic prostate cancer genes involved in proliferation, metastasis, angiogenesis, tumor suppression, apoptosis, and cellular stress responses.

Keywords: prostate cancer, genetic abnormality, tumor suppressor genes, oncogenes, inheritable genes, metastasis, apoptosis, transcription factors

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