摘要
顺铂是目前在临床上使用的领先的化疗药物之一。然而,它的严重的副作用和其抗肿瘤细胞的发展阻碍了它的使用。为了减少其副作用并保持抗癌效率,各种顺铂为基础的制剂进行了开发。在这篇综述中,我们总结了顺铂传递策略的最新进展,包括直接传递、传递前体药物和组合传递。识别了阻碍改进药物制剂发展的关键性挑战,并总结了有效的方法去解决在这些最近的论文中所提到的问题。
关键词: 顺铂;组合递送;药物递送;耐药性;前药;肿瘤治疗
Current Cancer Drug Targets
Title:Current Strategy for Cisplatin Delivery
Volume: 16 Issue: 6
Author(s): Zhanguo Yue, Zhiqiang Cao
Affiliation:
关键词: 顺铂;组合递送;药物递送;耐药性;前药;肿瘤治疗
摘要: Cisplatin is one of the leading chemotherapy drugs currently used in clinical settings. However, its serious side effects and its resistance developed by tumor cells hinder its usage. To decrease its side effects and maintain anti-cancer efficiency, various cisplatin based formulations were developed. In this minireview, we summarized the recent progress of cisplatin delivery strategies, including direct delivery, prodrug delivery and combination delivery. Key challenges preventing the development of improved drug formulations were identified, and effective approaches to address these issues were discussed in the context of these recent works.
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Zhanguo Yue, Zhiqiang Cao , Current Strategy for Cisplatin Delivery, Current Cancer Drug Targets 2016; 16 (6) . https://dx.doi.org/10.2174/1568009616666160328113006
DOI https://dx.doi.org/10.2174/1568009616666160328113006 |
Print ISSN 1568-0096 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5576 |
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