Abstract
Neurotransmitter and receptor systems are involved in different neurological and neuropsychological disorders such as Parkinson's disease, depression, Alzheimer’s disease and epilepsy. Recent advances in studies of signal transduction pathways or interacting proteins of neurotransmitter receptor systems suggest that different receptor systems may share the common signal transduction pathways or interacting proteins which may be better therapeutic targets for development of drugs to effectively control brain diseases. In this paper, we reviewed metabotropic glutamate receptors (mGluRs) and their related signal transduction pathways or interacting proteins in status epilepticus and temporal lobe epilepsy, and proposed some novel therapeutical drug targets for controlling epilepsy and epileptogenesis.
Keywords: Calmodulin, drug target, epileptogenesis, homer, interacting proteins, metabotropic glutamate receptors (mGluRs), protein kinase C (PKC), signal transduction pathways.
Current Neuropharmacology
Title:Metabotropic Glutamate Receptors and Interacting Proteins in Epileptogenesis
Volume: 14 Issue: 5
Author(s): Feng Qian and Feng-Ru Tang
Affiliation:
Keywords: Calmodulin, drug target, epileptogenesis, homer, interacting proteins, metabotropic glutamate receptors (mGluRs), protein kinase C (PKC), signal transduction pathways.
Abstract: Neurotransmitter and receptor systems are involved in different neurological and neuropsychological disorders such as Parkinson's disease, depression, Alzheimer’s disease and epilepsy. Recent advances in studies of signal transduction pathways or interacting proteins of neurotransmitter receptor systems suggest that different receptor systems may share the common signal transduction pathways or interacting proteins which may be better therapeutic targets for development of drugs to effectively control brain diseases. In this paper, we reviewed metabotropic glutamate receptors (mGluRs) and their related signal transduction pathways or interacting proteins in status epilepticus and temporal lobe epilepsy, and proposed some novel therapeutical drug targets for controlling epilepsy and epileptogenesis.
Export Options
About this article
Cite this article as:
Qian Feng and Tang Feng-Ru, Metabotropic Glutamate Receptors and Interacting Proteins in Epileptogenesis, Current Neuropharmacology 2016; 14 (5) . https://dx.doi.org/10.2174/1570159X14666160331142228
DOI https://dx.doi.org/10.2174/1570159X14666160331142228 |
Print ISSN 1570-159X |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6190 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
The AMPAR Antagonist Perampanel Regulates Neuronal Necroptosis via Akt/GSK3β Signaling After Acute Traumatic Injury in Cortical Neurons
CNS & Neurological Disorders - Drug Targets Trafficking of Neuronal Two Pore Domain Potassium Channels
Current Neuropharmacology Recent Progress in the Pharmacology of Imidazo[1,2-a]pyridines
Mini-Reviews in Medicinal Chemistry Understanding Genotypes and Phenotypes of the Mutations in Voltage- Gated Sodium Channel α Subunits in Epilepsy
CNS & Neurological Disorders - Drug Targets Characterisation of a Neural Teratogenicity Assay Based on Human ESCs Differentiation Following Exposure to Valproic Acid
Current Medicinal Chemistry Neural Progenitors and HIV-1- Associated Central Nervous System Disease in Adults and Children
Current HIV Research Recent Advances in Epilepsy
Current Neuropharmacology Clozapine Safety, 35 Years Later
Current Drug Safety Benzothiazoles - Scaffold of Interest for CNS Targeted Drugs
Current Medicinal Chemistry Anti-Inflammatory Immunotherapy for Multiple Sclerosis/Experimental Autoimmune Encephalomyelitis (EAE) Disease
Current Medicinal Chemistry Liverworts-Potential Source of Medicinal Compounds
Current Pharmaceutical Design synthesis and Structure-Activity Relationships of 2,3-Benzodiazepines as AMPA Receptor Antagonists
Mini-Reviews in Medicinal Chemistry Adverse Drug Reactions of Anti-Epileptic Drugs in Children with Epilepsy: A Cross-Sectional Study
Current Drug Safety Sodium Channel Inhibitor Drug Discovery Using Automated High Throughput Electrophysiology Platforms
Combinatorial Chemistry & High Throughput Screening Dynorphin Convertases and their Functions in CNS
Current Pharmaceutical Design Damaged Proteins Bearing L-Isoaspartyl Residues and Aging: A Dynamic Equilibrium Between Generation of Isomerized Forms and Repair by PIMT
Current Aging Science Patent Annotations
Recent Patents on CNS Drug Discovery (Discontinued) Rethinking the Excitotoxic Ionic Milieu:The Emerging Role of Zn 2+ in Ischemic Neuronal Injury
Current Molecular Medicine University of Kentucky Sanders-Brown Healthy Brain Aging Volunteers: Donor Characteristics, Procedures and Neuropathology
Current Alzheimer Research Drug Repositioning: Antimalarial Activities of GABA Analogs in Mice Infected with <i>Plasmodium berghei</i>
Central Nervous System Agents in Medicinal Chemistry