摘要
积累的DNA损伤和损伤DNA修复系统参与不同的神经退行性疾病的发病机制。当DNA损伤太广泛,DNA损伤反应途径触发了细胞衰老或凋亡。然而,DNA损伤增加的水平是否在神经退行性疾病中是神经退行性的事件的原因而不是结果还有待建立。在可能的DNA损伤、DNA双链断裂(双边带)是罕见的事,然而它们是最致命的形式的DNA损伤。在神经元中,双边带尤其有害,因为它们比增殖细胞的DNA修复能力更低。 在这里,我们提供双边带修复系统的描述和形容人类研究显示几种类型的DNA损伤的存在主要在三个神经退行性疾病,包括阿尔茨海默病(AD)、帕金森病(PD)和亨廷顿氏病(HD)。然后,我们分析双边带的作用缺乏积累和双边带修复系统的神经退化通过研究神经退行性疾病的动物模型来检查。
关键词: 阿尔茨海默氏症、DNA损伤、DNA修复、DNA双链断裂、亨廷顿氏舞蹈症、神经退行性疾病、帕金森病。
Current Alzheimer Research
Title:DNA Double Strand Breaks: A Common Theme in Neurodegenerative Diseases
Volume: 13 Issue: 11
Author(s): Daniela Merlo, Cristiana Mollinari, Mauro Racaniello, Enrico Garaci, Alessio Cardinale
Affiliation:
关键词: 阿尔茨海默氏症、DNA损伤、DNA修复、DNA双链断裂、亨廷顿氏舞蹈症、神经退行性疾病、帕金森病。
摘要: Accumulation of DNA damage and impairment of DNA repair systems are involved in the pathogenesis of different neurodegenerative diseases. Whenever DNA damage is too extensive, the DNA damage response pathway provides for triggering cellular senescence and/or apoptosis. However, whether the increased level of DNA damage in neurodegenerative disorders is a cause rather than the consequence of neurodegenerative events remains to be established. Among possible DNA lesions, DNA double strand breaks (DSBs) are rare events, nevertheless they are the most lethal form of DNA damage. In neurons, DSBs are particularly deleterious because of their reduced DNA repair capability as compared to proliferating cells.
Here, we provide a description of DSB repair systems and describe human studies showing the presence of several types of DNA lesions in three major neurodegenerative diseases including Alzheimer’s disease (AD), Parkinson’s disease (PD) and Huntington’s disease (HD). Then, we analyze the role of DSB accumulation and deficiency of DSB repair systems in neurodegeneration by examining studies on animal models of neurodegenerative diseases.
Export Options
About this article
Cite this article as:
Daniela Merlo, Cristiana Mollinari, Mauro Racaniello, Enrico Garaci, Alessio Cardinale , DNA Double Strand Breaks: A Common Theme in Neurodegenerative Diseases, Current Alzheimer Research 2016; 13 (11) . https://dx.doi.org/10.2174/1567205013666160401114915
DOI https://dx.doi.org/10.2174/1567205013666160401114915 |
Print ISSN 1567-2050 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5828 |
Call for Papers in Thematic Issues
New Advances in the Prevention, Diagnosis, Treatment, and Rehabilitation of Alzheimer's Disease
Aims and Scope: Introduction: Alzheimer's disease (AD) poses a significant global health challenge, with an increasing prevalence that demands concerted efforts to advance our understanding and strategies for prevention, diagnosis, treatment, and rehabilitation. This thematic issue aims to bring together cutting-edge research and innovative approaches from multidisciplinary perspectives to address ...read more
Current updates on the Role of Neuroinflammation in Neurodegenerative Disorders
Neuroinflammation is an invariable hallmark of chronic and acute neurodegenerative disorders and has long been considered a potential drug target for Alzheimer?s disease (AD) and dementia. Significant evidence of inflammatory processes as a feature of AD is provided by the presence of inflammatory markers in plasma, CSF and postmortem brain ...read more
Deep Learning for Advancing Alzheimer's Disease Research
Alzheimer's disease (AD) poses a significant global health challenge, with an increasing number of individuals affected yearly. Deep learning, a subfield of artificial intelligence, has shown immense potential in various domains, including healthcare. This thematic issue of Current Alzheimer Research explores the application of deep learning techniques in advancing our ...read more
Diagnostic and therapeutic biomarkers of dementia
Dementia affects 18 million people worldwide. Dementia is a syndrome of symptoms caused by brain disease, usually chronic or progressive, clinically characterized by multiple impairments of higher cortical functions such as memory, thinking, orientation, and learning. In addition, in the course of dementia, cognitive deficits are observed, which often hinder ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Thymoquinone Anticancer Discovery: Possible Mechanisms
Current Drug Discovery Technologies Big Data to Knowledge: Application of Machine Learning to Predictive Modeling of Therapeutic Response in Cancer
Current Genomics Pharmacological Activation of p53 in Cancer Cells
Current Pharmaceutical Design RGD-based Therapy: Principles of Selectivity
Current Pharmaceutical Design Targeting Cancer Stem Cell Lines as a New Treatment of Human Cancer
Recent Patents on Anti-Cancer Drug Discovery The Immune System of Cancer Patients
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry Lactate Transporters and pH Regulation: Potential Therapeutic Targets in Glioblastomas
Current Cancer Drug Targets Cytostatic Properties of Some Angiotensin I Converting Enzyme Inhibitors and of Angiotensin II Type I Receptor Antagonists
Current Pharmaceutical Design Histone Deacetylase Inhibitor Trichostatin A Suppresses Cell Proliferation and Induces Apoptosis by Regulating the PI3K/AKT Signalling Pathway in Gastric Cancer Cells
Anti-Cancer Agents in Medicinal Chemistry Understanding Epigenetic Alterations in Alzheimer's and Parkinson's Disease: Towards Targeted Biomarkers and Therapies
Current Pharmaceutical Design Fatty Acid Synthase: A Target for the Reversal of Liver Steatosis
Current Enzyme Inhibition Lipid Modulation of Intravascular and Cellular Sodium Handling:Mechanistic Insights and Potential Clinical Implications
Current Vascular Pharmacology Molecular Mechanism of Inhibition of Polysialyltransferase Domain (PSTD) by Heparin
Current Topics in Medicinal Chemistry 1,2,3-Triazine Scaffold as a Potent Biologically Active Moiety: A Mini Review
Mini-Reviews in Medicinal Chemistry Development of NGR-Based Anti-Cancer Agents for Targeted Therapeutics and Imaging
Anti-Cancer Agents in Medicinal Chemistry Polymeric Carriers for Gene Delivery: Chitosan and Poly(amidoamine) Dendrimers
Current Pharmaceutical Design Multi-targeting the Entrance Door to Block HIV-1
Current Drug Targets - Infectious Disorders Protective Effects of Pomegranate in Endothelial Dysfunction
Current Pharmaceutical Design Synthesis and Biological Activities of Substituted Benzoxazepine: A Review
Mini-Reviews in Organic Chemistry Proteasome Inhibitors: Recent Advances and New Perspectives In Medicinal Chemistry
Current Topics in Medicinal Chemistry