Abstract
Background: Now a day’s natural polymer based nanoparticulate system have been widely studied as particulate vehicles in the bio-medical and pharmaceutical area. Alginate, a natural biopolymer show good biodegradability, biocompatibility and non toxic, has received attention to utilise as a carrier for preparation of polymeric nanoparticles. Chemically and physically alginate can modified easily and obtained various structure having various properties, and versatile applications. Various properties and structure such as biodegradability, gelling property, mechanical strength and cell affinity can be obtained through combination of alginate with other biopolymers, immobilization of specific molecules such as sugar molecules and peptide through chemical or physical cross-linking. Conclusion: In this article, we report different method of preparation of alginate nanoparticles, and also focus on recent advances of nanoparticles made of alginate and its modified form in the field of drug delivery applications.
Keywords: Alginate, Nanoparticles, Nano-aggregates, Nanocapsules, Nanospheres, Drug delivery.
Current Pharmaceutical Design
Title:Alginate Based Nanocarriers for Drug Delivery Applications
Volume: 22 Issue: 22
Author(s): Sougata Jana, Kalyan Kumar Sen and Arijit Gandhi
Affiliation:
Keywords: Alginate, Nanoparticles, Nano-aggregates, Nanocapsules, Nanospheres, Drug delivery.
Abstract: Background: Now a day’s natural polymer based nanoparticulate system have been widely studied as particulate vehicles in the bio-medical and pharmaceutical area. Alginate, a natural biopolymer show good biodegradability, biocompatibility and non toxic, has received attention to utilise as a carrier for preparation of polymeric nanoparticles. Chemically and physically alginate can modified easily and obtained various structure having various properties, and versatile applications. Various properties and structure such as biodegradability, gelling property, mechanical strength and cell affinity can be obtained through combination of alginate with other biopolymers, immobilization of specific molecules such as sugar molecules and peptide through chemical or physical cross-linking. Conclusion: In this article, we report different method of preparation of alginate nanoparticles, and also focus on recent advances of nanoparticles made of alginate and its modified form in the field of drug delivery applications.
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Cite this article as:
Jana Sougata, Kumar Sen Kalyan and Gandhi Arijit, Alginate Based Nanocarriers for Drug Delivery Applications, Current Pharmaceutical Design 2016; 22 (22) . https://dx.doi.org/10.2174/1381612822666160510125718
DOI https://dx.doi.org/10.2174/1381612822666160510125718 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
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