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Current Protein & Peptide Science


ISSN (Print): 1389-2037
ISSN (Online): 1875-5550

Review Article

“Bridge Proteins” Link Inflammation and Metabolic Diseases: Potential Targets for Therapeutics

Author(s): Hailong Jiang, Guixin Qin, Xuefeng Zhang and Dongsheng Che*

Volume 18, Issue 6, 2017

Page: [619 - 629] Pages: 11

DOI: 10.2174/1389203717666160627081207

Price: $65


Clinical observations support the postulate that chronic low-grade inflammation underlies metabolic diseases and inflammatory mediators can trigger some metabolic diseases. In disorder condition, what is the first one: metabolic diseases cause inflammation or conversely? This “chicken or egg” type question was hard to answer. However, instead of focusing on this difficult issue, we should ask another challenging question: what are the links between inflammation and metabolic diseases? Seizing the key from this chaos may be the best way to solve the problem and break the cycle. To answer this question, we review the regulators (such as NF-κB, PPARs, mTOR, and STAT3) that have important roles in both metabolism and inflammation. These “bridge proteins” that link metabolic diseases and inflammation not only increase our understanding of these two diseases, but also provide potential targets for therapeutics and practical clinical applications.

Keywords: Inflammation, metabolic disease, NF-κB, PPARs, mTOR, STAT3.

Graphical Abstract

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