摘要
间充质干细胞是一种梭形贴壁的多能干细胞,它能分化为多种专门的细胞类型,包括成骨细胞、软骨细胞和脂肪细胞。它们从许多组织和器官中分离出来,并有助于多种组织的维持和再生。除了它们的自我更新能力,它们最近被证实具有临床或治疗潜力特别是免疫调节特性。事实上,最近的研究表明间充质干细胞在实验性自身免疫性疾病的治疗中的潜在应用。结果表明,它们的影响部分是由刺激或者抑制靶细胞过程中可溶性因子或者细胞外囊泡(包括外泌体和微泡)的释放所介导。本文将描述间充质干细胞的分泌组,关注与它们的免疫调节活性相关的成分。
关键词: 间充质干细胞, 分泌组, 可溶性因子, 免疫调节, 细胞外囊泡, 外来物
Current Medicinal Chemistry
Title:The Immunoregulatory Activity of Mesenchymal Stem Cells: ‘State of Art’ and ‘Future Avenues’
Volume: 23 Issue: 27
Author(s): Alessandra Fierabracci, Andrea Del Fattore, Maurizio Muraca
Affiliation:
关键词: 间充质干细胞, 分泌组, 可溶性因子, 免疫调节, 细胞外囊泡, 外来物
摘要: Mesenchymal stem cells are spindle-like plastic adherent multipotent cells that can differentiate into multiple specialized cell types including osteoblasts, chondrocytes and adipocytes. They were isolated from many tissues and organs and they contribute to the maintenance and regeneration of several tissues. Besides their ability of self-renewal, they have recently been shown to have a clinical/therapeutic potential particularly for their immunomodulatory properties. Indeed recent studies suggested a potential application of MSCs for the treatment of experimental autoimmune disorders. It was demonstrated that their effects are in part mediated by the release of soluble factors or extracellular vesicles, including exosomes and microvesicles, stimulating or inhibiting target cells. This review will describe the secretome of MSCs, pointing the attention on the components relevant for their immunodulatory activities.
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Alessandra Fierabracci, Andrea Del Fattore, Maurizio Muraca , The Immunoregulatory Activity of Mesenchymal Stem Cells: ‘State of Art’ and ‘Future Avenues’, Current Medicinal Chemistry 2016; 23 (27) . https://dx.doi.org/10.2174/0929867323666160627112827
DOI https://dx.doi.org/10.2174/0929867323666160627112827 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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