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Letters in Drug Design & Discovery


ISSN (Print): 1570-1808
ISSN (Online): 1875-628X

Review Article

Anti-inflammatory Potential of Alkaloids as a Promising Therapeutic Modality

Author(s): Marya and Haroon Khan

Volume 14, Issue 2, 2017

Page: [240 - 249] Pages: 10

DOI: 10.2174/1570180813666160712224752

Price: $65


Inflammation and its treatment has been studied for thousands of years and is characterized as a nonspecific but beneficial response of tissues to injury. Inflammation is distinguished by symptoms such as redness, pain, and swelling. The anti-inflammatory agents are used to encounter inflammation. It has been found that conventional synthetic nonsteroidal anti-inflammatory drugs (NSAIDs) are effective in various inflammatory conditions but associated with gastrointestinal, liver and kidney problems. Therefore, natural products could be an ideal therapeutic alternative. Our review encounters all the alkaloids with anti-inflammatory effect and/or possible mechanism where reported. It is concluded that further detail mechanistic and clinical studies could lead to the discovery of more effective therapeutic agents in the class.

Keywords: Alkaloids, anti-inflammatory activity, possible mechanism.

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