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Protein & Peptide Letters


ISSN (Print): 0929-8665
ISSN (Online): 1875-5305

Review Article

A Review on Structures and Functions of Bcl-2 Family Proteins from Homo sapiens

Author(s): Dakshinamurthy Sivakumar and Thirunavukkarasu Sivaraman

Volume 23, Issue 10, 2016

Page: [932 - 941] Pages: 10

DOI: 10.2174/0929866523666160719094636

Price: $65


Cancer cells evade apoptosis, which is regulated by proteins of Bcl-2 family in the intrinsic pathways. Numerous experimental three-dimensional (3D) structures of the apoptotic proteins and the proteins bound with small chemical molecules/peptides/proteins have been reported in the literature. In this review article, the 3D structures of the Bcl-2 family proteins from Homo sapiens and as well complex structures of the anti-apoptotic proteins bound with small molecular inhibitors reported in the literature to date have been comprehensively listed out and described in detail. Moreover, the molecular mechanisms by which the Bcl-2 family proteins modulate the apoptotic processes and strategies for designing antagonists to anti-apoptotic proteins have been concisely discussed.

Keywords: Apoptosis, Bcl-2 family proteins, anti-cancer compounds and structure-function relationships.

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