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Current Drug Metabolism

Editor-in-Chief

ISSN (Print): 1389-2002
ISSN (Online): 1875-5453

Review Article

Significance of Pharmacogenetics and Pharmacogenomics Research in Current Medical Practice

Author(s): Swayam Prakash and Suraksha Agrawal

Volume 17, Issue 9, 2016

Page: [862 - 876] Pages: 15

DOI: 10.2174/1389200217666160804150959

Price: $65

Abstract

Human genome sequencing highlights the involvement of genetic variation towards differential risk of human diseases, presence of different phenotypes, and response to pharmacological elements. This brings the field of personalized medicine to forefront in the era of modern health care. Numerous recent approaches have shown that how variation in the genome at single nucleotide level can be used in pharmacological research. The two broad aspects that deal with pharmacological research are pharmacogenetics and pharmacogenomics. This review encompasses how these variations have created the basis of pharmacogenetics and pharmacogenomics research and important milestones accomplished in these two fields in different diseases. It further discusses at length their importance in disease diagnosis, response of drugs, and various treatment modalities on the basis of genetic determinants.

Keywords: Pharmacogenetics, pharmacogenomics, personalized medicine, monogenic disorder, polygenic disorder, genetic testing.

Graphical Abstract

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