Generic placeholder image

Current Pharmaceutical Analysis


ISSN (Print): 1573-4129
ISSN (Online): 1875-676X

Research Article

Analysis of the Antiallergenic Drug Promethazine with Ruthenium (III)

Author(s): Mukul Sharma, Afraim Koty and Abdul Jabbar Al-Rajab*

Volume 13, Issue 6, 2017

Page: [525 - 531] Pages: 7

DOI: 10.2174/1573412912666160805124142

Price: $65


Introduction: An accurate and precise spectrophotometric method has been developed for the determination of the antiallergenic drug, promethazine with ruthenium (III).

Methods: The proposed method involves complexation of promethazine with Ru (III) (PM.Ru(III)) at 60ºC and λmax = 510 nm, which is applicable in pharmaceutical tablets and analytical data. The values for Beer's law, molar absorptivity, Sandell’s sensitivity, and mean correlation coefficient were determined to be 0.2-28 µg mL-1, 1.54 x 103 L mol-1cm-1, 0.021 and 0.9996, respectively.

Conclusion: The complex of promethazine with Ru(III) was characterised using FTIR, 1H-NMR, ESR, magnetic susceptibility, thermal (TG-DTA), and PXRD. The most plausible structure for the complex is reported with molecular formula [C37H52ClN4O2RuS2]·3Cl. The proposed method could be implemented for an easy and effective analysis for promethazine.

Keywords: Promethazine, drug, Ru(III), spectrophotometric, detection, FTIR.

Graphical Abstract

Rights & Permissions Print Cite
© 2024 Bentham Science Publishers | Privacy Policy