摘要
阿尔茨海默病和帕金森病是世界范围内普遍存在的神经退行性疾病,其本质与衰老有关。在纳米药物输送系统显著的时代,如今一些给药系统已应用于对这些疾病的治疗,如脂质体,胶束纳米粒子(聚合物、脂质、金属和无机离子),外泌体,树枝状聚合物和富勒烯。与传统的药物剂型相比,这些给药系统的优点是他们能促进药物通过血脑屏障(BBB),使前体靶向降解,提高治疗效果。本文为治疗阿尔茨海默氏症和帕金森氏病,对最先进的药物输送系统进行了研究。本文首先对中枢神经系统(中枢神经系统)和这些疾病的发展中所涉及的机制进行了简短的描述,然后介绍了一些用于治疗这些神经退行性疾病的药物的例子,这些药物已用于传统的药物剂型,并正在开发新的药物给药系统。
关键词: 阿尔茨海默病、帕金森病、脂质体、胶束、纳米粒子,外泌体,树枝状大分子,富勒烯
Current Medicinal Chemistry
Title:Therapeutic Strategies for Alzheimer's and Parkinson's Diseases by Means of Drug Delivery Systems
Volume: 23 Issue: 31
Author(s): S. Cunha, M. H. Amaral, J. M. Sousa Lobo, A. C. Silva
Affiliation:
关键词: 阿尔茨海默病、帕金森病、脂质体、胶束、纳米粒子,外泌体,树枝状大分子,富勒烯
摘要: Alzheimer’s and Parkinson’s diseases are prevalent neurodegenerative disorders worldwide, which are essentially related to aging. Within the remarkable era of nanomedicine, nowadays several delivery systems have been suggested to improve the treatment of these disorders, namely, liposomes, micelles, nanoparticles (polymeric, lipid, metallic and inorganic), exosomes, dendrimers and fullerenes. The advantage that has been claimed to these delivery systems is that they facilitate the passage of drugs through the blood brain barrier (BBB), enabling targeting before body degradation, and increasing therapeutic efficacy, comparied to conventional pharmaceutical dosage forms.
This review article provides a state of the art regarding the drug delivery systems that have been studied for the treatment of Alzheimer’s and Parkinson’s diseases. It begins with a brief description of the central nervous system (CNS) and the mechanisms involved in the development of these diseases. Later, some examples of drugs used in the treatment of these neurodegenerative diseases are presented, which are currently available in conventional pharmaceutical dosage forms, and in new drug delivery systems that are under development.
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S. Cunha, M. H. Amaral, J. M. Sousa Lobo, A. C. Silva , Therapeutic Strategies for Alzheimer's and Parkinson's Diseases by Means of Drug Delivery Systems, Current Medicinal Chemistry 2016; 23 (31) . https://dx.doi.org/10.2174/0929867323666160824162401
DOI https://dx.doi.org/10.2174/0929867323666160824162401 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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