Abstract
Targeting of MMP-9 could be a useful approach for anticancer therapy. The inhibitory activities of 23 flavonoids on tumor necrosis factors alpha (TNF)-induced matrix metalloproteinases 9 (MMP-9) gene expression were analyzed quantitatively. To elucidate the relationships between the structural properties of flavonoids and their inhibitory activities, comparative molecular field analysis and comparative molecular similarity indices analysis were carried out. The structural conditions required for high inhibitory activity towards TNF-induced MMP-9 gene expression were derived. In addition, for spiraeoside, which showed the best activity among the test compounds, reverse transcription polymerase chain reaction (PCR), real-time PCR analysis, and promoter-reporter assay were performed. Spiraeoside could be a lead compound for the anticancer agents.
Keywords: Matrix metallopeptidase 9, CoMFA, CoMSIA, flavonoid, spiraeoside.
Letters in Drug Design & Discovery
Title:Relationships Between the Structural Properties of Flavonoids and their Inhibitory Activities Against Matrix Metallopeptidase 9
Volume: 14 Issue: 1
Author(s): Soon Young Shin, Hyeryoung Jung, Yearam Jung, Beom Soo Kim, Young Han Lee and Yoongho Lim
Affiliation:
Keywords: Matrix metallopeptidase 9, CoMFA, CoMSIA, flavonoid, spiraeoside.
Abstract: Targeting of MMP-9 could be a useful approach for anticancer therapy. The inhibitory activities of 23 flavonoids on tumor necrosis factors alpha (TNF)-induced matrix metalloproteinases 9 (MMP-9) gene expression were analyzed quantitatively. To elucidate the relationships between the structural properties of flavonoids and their inhibitory activities, comparative molecular field analysis and comparative molecular similarity indices analysis were carried out. The structural conditions required for high inhibitory activity towards TNF-induced MMP-9 gene expression were derived. In addition, for spiraeoside, which showed the best activity among the test compounds, reverse transcription polymerase chain reaction (PCR), real-time PCR analysis, and promoter-reporter assay were performed. Spiraeoside could be a lead compound for the anticancer agents.
Export Options
About this article
Cite this article as:
Shin Young Soon, Jung Hyeryoung, Jung Yearam, Kim Soo Beom, Lee Han Young and Lim Yoongho, Relationships Between the Structural Properties of Flavonoids and their Inhibitory Activities Against Matrix Metallopeptidase 9, Letters in Drug Design & Discovery 2017; 14 (1) . https://dx.doi.org/10.2174/1570180813666160919161434
DOI https://dx.doi.org/10.2174/1570180813666160919161434 |
Print ISSN 1570-1808 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-628X |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Nicotine, Body Weight and Potential Implications in the Treatment of Obesity
Current Topics in Medicinal Chemistry Drug Target Identification for Neuronal Apoptosis Through a Genome Scale Screening
Current Medicinal Chemistry Proteomic Approaches in Plant Biology
Current Proteomics New Developments in Targeted Analysis of Protein Posttranslational Modifications
Current Proteomics Restoring TRAIL Induced Apoptosis Using Naturopathy. Hercules Joins Hand with Nature to Triumph Over Lernaean Hydra
Current Genomics Recent Patents of Gene Sequences Relative to the Phosphatidylinositol 3-kinase / Akt Pathway and their Relevance to Drug Discovery
Recent Patents on DNA & Gene Sequences Inflammation and Cancer: When NF-κB Amalgamates the Perilous Partnership
Current Cancer Drug Targets 3,4,5-Trisubstituted-1,2,4-triazole Derivatives as Antiproliferative Agents: Synthesis, In vitro Evaluation and Molecular Modelling
Letters in Drug Design & Discovery The Promise of Slow Down Ageing May Come from Curcumin
Current Pharmaceutical Design Recent Developments of Platinum-based Anticancer Drugs- Detection and Analysis in Biological Samples
Current Organic Chemistry Pathobiology of Head and Neck Squamous Tumorigenesis
Current Cancer Drug Targets Armed Oncolytic Adenoviruses and Polymer-shielded Nanocomplex for Systemic Delivery
Current Cancer Therapy Reviews Steroid Biosynthesis Inhibitors in the Therapy of Hypercortisolism: Theory and Practice
Current Medicinal Chemistry From Pituitary Adenoma to Pituitary Neuroendocrine Tumors: How Molecular Pathways may Impact the Therapeutic Management?
Endocrine, Metabolic & Immune Disorders - Drug Targets Pisosterol Induces G2/M Cell Cycle Arrest and Apoptosis via the ATM/ATR Signaling Pathway in Human Glioma Cells
Anti-Cancer Agents in Medicinal Chemistry TGFb and its Smad Connection to Cancer
Current Genomics Viral Based Gene Therapy for Prostate Cancer
Current Gene Therapy Nutritional Antioxidants Mechanisms of Action, Analyses of Activities and Medical Applications
Current Medicinal Chemistry - Immunology, Endocrine & Metabolic Agents Impact of Environmental Endocrine Disruption on the Reproductive System for Human Health
Immunology, Endocrine & Metabolic Agents in Medicinal Chemistry (Discontinued) Recent Developments in Patented DC-Based Immunotherapy for Various Malignancies
Recent Patents on Regenerative Medicine