Abstract
The severe side effects of currently available cancer therapies led focus on a natural product, Curcumin, which has been traditionally used in Indian medicine from centuries. Curcumin has potential to act against various diseases including cancer. This review describes, Curcumin as safe, multitargeted lead molecule in anticancer drug development, and current advances in chemical modification of the basic structure to overcome its limitations. Curcumin showed various biological activities including cancer chemoprevention and anticancer in vitro, in vivo and Phase I clinical trials. The improved solubility and potency of synthesized monocarbonyl analogues (MACs) and diarylidenylpiperidone (DAPs) analogs motivate the researchers to harness its safe, multitargeted and immune system modulator properties.
Keywords: Anti-inflammation, apoptosis, chemotherapeutic agents, cytotoxic, metabolites, monocarbonyl analogues, traditional medicine.
Graphical Abstract
Call for Papers in Thematic Issues
Applications of Molecular Descriptors in Physicochemical Properties Research of Organic Compounds
Chemical graph theory is concerned with all aspects of the application of graph theory to various areas of chemistry, including organic, theoretical, mathematical, and computational chemistry, as well as in bioinformatics and computational biology. By the use of the term chemical it is emphasized that one is allowed in chemical ...read more
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This special issue explores the transformative impact of two-dimensional (2D) materials on the realm of organic chemistry, unraveling new possibilities for synthesis, functionalization, and applications of organic compounds. Focused on the unique chemistry within this novel dimension, the issue highlights breakthroughs in the field of 2D organic chemistry. Contributions are ...read more
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