Abstract
Herein, we report a 70-year-old male patient, with recurrent multiple hepatic abscesses, that was admitted to the internal medicine department for treatment of Carbapenem Resistant Escherichia Coli (CRE) bacteremia.
The patient was treated with Tigecycline; few days later, he developed "Disseminated Intravascular Coagulation (DIC)" like coagulation study abnormality that seemed to be related to Tigecycline treatment. Upon discontinuing it, the DIC-like condition was resolved. Tigecycline should be considered as a possible etiological factor in patients with DIC-like, and this therapy should be withdrawn immediately in suspected cases.Keywords: Coagulation disorder, DIC, hypofibrinogenemia, Tigecycline, thrombocytopenia.
Current Drug Safety
Title:Severe Coagulation Disorder and Thrombocytopenia Associated with Tigecycline – Case Report and Review of Literature
Volume: 12 Issue: 1
Author(s): Sami Giryes, Zaher S. Azzam, Reem Ismael-Badarneh, Norberto Krivoy and Gidon Berger
Affiliation:
Keywords: Coagulation disorder, DIC, hypofibrinogenemia, Tigecycline, thrombocytopenia.
Abstract: Herein, we report a 70-year-old male patient, with recurrent multiple hepatic abscesses, that was admitted to the internal medicine department for treatment of Carbapenem Resistant Escherichia Coli (CRE) bacteremia.
The patient was treated with Tigecycline; few days later, he developed "Disseminated Intravascular Coagulation (DIC)" like coagulation study abnormality that seemed to be related to Tigecycline treatment. Upon discontinuing it, the DIC-like condition was resolved. Tigecycline should be considered as a possible etiological factor in patients with DIC-like, and this therapy should be withdrawn immediately in suspected cases.Export Options
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Cite this article as:
Giryes Sami, Azzam S. Zaher, Ismael-Badarneh Reem, Krivoy Norberto and Berger Gidon, Severe Coagulation Disorder and Thrombocytopenia Associated with Tigecycline – Case Report and Review of Literature, Current Drug Safety 2017; 12 (1) . https://dx.doi.org/10.2174/1574886311666160920090714
DOI https://dx.doi.org/10.2174/1574886311666160920090714 |
Print ISSN 1574-8863 |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-3911 |
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