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Current Medicinal Chemistry


ISSN (Print): 0929-8673
ISSN (Online): 1875-533X

Function and Regulation of Tumor Necrosis Factor Receptor Type 2

Author(s): I. Carpentier, B. Coornaert and R. Beyaert

Volume 11, Issue 16, 2004

Page: [2205 - 2212] Pages: 8

DOI: 10.2174/0929867043364694

Price: $65


TNF is a major proinflammatory cytokine, which exerts its effects through two different receptors known as TNF-R1 and TNF-R2. Whereas TNF-R1 induced signaling pathways have been very well characterized during the past years, TNF-R2 has been much less well studied. Nevertheless, the function of TNF-R2 should not be underestimated, the more because this receptor shows a much more restricted but inducible expression. Several inflammatory diseases and cancers show upregulated levels of soluble TNF-R2 or are associated with TNF-R2 polymorphisms, implicating an important role for TNF-R2 as a therapeutic target. Here we will review the mechanisms that regulate TNF-R2 expression, as well as discuss TNF-R2 induced signal transduction and cross-talk with TNF-R1.

Keywords: tumor necrosis factor receptor (tnf-r), signal transduction, apoptosis, inflammation, cd120b, disease, polymorphisms

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