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Current Pharmaceutical Design


ISSN (Print): 1381-6128
ISSN (Online): 1873-4286

Review Article

Inflammation: A Novel Therapeutic Target/Direction in Atherosclerosis

Author(s): Bin Li, Weihong Li, Xiaoli Li and Hong Zhou*

Volume 23, Issue 8, 2017

Page: [1216 - 1227] Pages: 12

DOI: 10.2174/1381612822666161230142931

Price: $65


Over the past two decades, the viewpoint of atherosclerosis has been replaced gradually by a lipiddriven, chronic, low-grade inflammatory disease of the arterial wall. Current treatment of atherosclerosis is focused on limiting its risk factors, such as hyperlipidemia or hypertension. However, treatment targeting the inflammatory nature of atherosclerosis is still very limited and deserves further attention to fight atherosclerosis successfully. Here, we review the current development of inflammation and atherosclerosis to discuss novel insights and potential targets in atherosclerosis, and to address drug discovery based on anti-inflammatory strategy in atherosclerotic disease.

Keywords: Atherosclerosis, inflammation, drug discovery, target identification.

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