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Current Cancer Drug Targets


ISSN (Print): 1568-0096
ISSN (Online): 1873-5576

Review Article

The Linkage Between Inflammation and Immune Tolerance: Interfering with Inflammation in Cancer

Author(s): Vladimir Stanislavovich Rogovskii*

Volume 17, Issue 4, 2017

Page: [325 - 332] Pages: 8

DOI: 10.2174/1568009617666170109110816

Price: $65


Background: It is widely accepted that chronic inflammation critically contributes to cancer. Immune tolerance in cancer mediates tumor escape from the immune system. The mechanisms of relations between inflammation and immune tolerance are still not fully elucidated.

Objective: The main mechanisms that link inflammation and tolerance are considered. Drug targets that are in use to interfere with inflammation in cancer are discussed.

Conclusion: Inflammation mediates tumor-induced tolerance. The induction and the maintenance of the chronic inflammatory response is a universal mechanism of immune tolerance.

Keywords: Inflammation, resolution, immune tolerance, cancer immunotherapy, tumor immunology, tumor-induced tolerance.

Graphical Abstract

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