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Mini-Reviews in Medicinal Chemistry


ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

Review Article

Drug Discovery for Paediatric Chagas Disease

Author(s): Sreekanth Thota* and Carlos M. Morel

Volume 18, Issue 9, 2018

Page: [776 - 780] Pages: 5

DOI: 10.2174/1389557516666161226155204

Price: $65


Chagas disease is caused by the parasite Trypanosoma cruzi and is regularly found among particular people living in Central and South America. Paediatric Chagas disease occurs in 1-10% of infants of infected mothers. The major important point considered in the treatment of congenital Chagas disease focuses on killing the parasite in acute infection and managing signs and symptoms in later stages. Nowadays, two drugs benznidazole and nifurtimox are currently available in the market for the treatment of paediatric Chagas disease.

Keywords: Chagas disease, congenital, infants, symptoms, treatment, Trypanosoma cruzi.

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