摘要
背景:癌症代谢重编程重新激发了癌症耐药性代谢调控研究的积极性。越来越多的代谢调节剂与癌症药物联合在体外或体内研究中获得了预期的功效,这在临床试验研究中也是如此,这表明提高功效和降低耐药性的潜力很大。因此,对于合理的药物设计和临床癌症药物研究,对于抗癌药物中代谢调节剂的衰减的综合评述是必要的。 方法:采用抗癌药物和癌症代谢重编程为关键词收集书目数据库中具有参考价值的出版物。具体而言,焦点问题是代谢调节剂在抗癌改善方面的进展。根据纳入标准采用数字和表格分析干预措施。 结果:本综述总结了代谢调节剂与癌症药物联用在体外,体内和临床试验研究中的进展,特别是提高抗癌性。代谢调控与抗癌能力之间的关系被阐述了,并且潜在的代谢调节剂被包含了。代谢目标也在4个图中进行了分类,并在4个表中进行了阐述。系统地阐明了三种典型的代谢调节剂,即lonidamine,2-DG和3-BrPA,赋予了抗癌抗性的衰减。 结论:代谢调节是一种有针对性的干扰适度干预,反映稳态平衡。当与癌症药物结合时,代谢调节剂总是显示具有实际意义的激发潜力,增强活性或发挥协同作用。
关键词: 关键词:癌症抗性,癌症代谢重编程,代谢调节剂,lonidamine,2-脱氧-D葡萄糖,3-溴丙酮酸盐。
Current Medicinal Chemistry
Title:The Typical Metabolic Modifiers Conferring Improvement in Cancer Resistance
Volume: 24 Issue: 34
关键词: 关键词:癌症抗性,癌症代谢重编程,代谢调节剂,lonidamine,2-脱氧-D葡萄糖,3-溴丙酮酸盐。
摘要: Background: Cancer metabolic reprogramming rekindles enthusiasm for the research of metabolic regulation in cancer drug resistance. A growing number of metabolic modifiers combined with cancer drugs obtain the expected efficacy in in vitro or in vivo studies, also in clinical trial studies, indicating a good potential of enhancing efficacy and reducing resistance. Hence, a comprehensive review on the attenuations of metabolic modifiers in cancer drug resistance is necessary for rational drug design and clinical cancer drug research.
Methods: Cancer drug resistance and cancer metabolic reprogramming were used as the key words to collect publications with reference value in bibliographic databases. Specifically, the focused question is the advances of metabolic modifiers on cancer resistance improvement. Figures and tables were applied to analyze the interventions in accordance with the inclusion criteria.
Results: This review summarized the advances of metabolic modifiers combined with cancer drugs in in vitro, in vivo and clinical trial studies, especially for cancer resistance improvement. The relationship between metabolic regulation and cancer resistance was elaborated, and the potential metabolic modifiers were embraced. Metabolic targets were also visualized in categorization in 4 figures and expatiated in 4 tables. Three typical metabolic modifiers, namely lonidamine, 2-DG and 3-BrPA, conferring attenuation to cancer resistance were elucidated systematically.
Conclusion: Metabolic regulation is an intervention with targeted perturbation in a modest manner and reflects homeostasis balance. When combined with cancer drugs, the metabolic modifiers always show exciting potential with practical significance, enhancing activity or exerting synergism.
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The Typical Metabolic Modifiers Conferring Improvement in Cancer Resistance, Current Medicinal Chemistry 2017; 24 (34) . https://dx.doi.org/10.2174/0929867324666170203121449
DOI https://dx.doi.org/10.2174/0929867324666170203121449 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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