Abstract
Background: The Carrier linked prodrug as per literature is known to be a pharmacologically inactive chemical derivative and could be used to change the physicochemical properties of compounds. Codrugs is a type of carrier linked prodrug, and consist of two usually synergistic drugs or moieties attached to each other.
Objective: synthesis of codrug consists of two pharmacologically active compounds coupled together where one drug is the carrier for the other and vice versa. Result: It is a very beneficial area of research and its admittance in human therapy has given successful results clinically as well as therapeutically. Conclusion: The emphasis is carried on Benorylate, the Codrug of aspirin and paracetamol for improved anti-inflammatory and analgesic activity. The article also takes a review of the various applications of Codrugs and the development in this field during the last few decades.Keywords: Prodrugs, codrugs, carrier linked prodrugs, spacer, benorylate.
Current Drug Therapy
Title:Prodrugs to Codrugs
Volume: 12 Issue: 1
Author(s): Deepali Gangrade*Ravindra Karande
Affiliation:
- Department of Pharmaceutical Chemistry, Vivekanand Education Society College of Pharmacy, Chembur (E), Mumbai,India
Keywords: Prodrugs, codrugs, carrier linked prodrugs, spacer, benorylate.
Abstract: Background: The Carrier linked prodrug as per literature is known to be a pharmacologically inactive chemical derivative and could be used to change the physicochemical properties of compounds. Codrugs is a type of carrier linked prodrug, and consist of two usually synergistic drugs or moieties attached to each other.
Objective: synthesis of codrug consists of two pharmacologically active compounds coupled together where one drug is the carrier for the other and vice versa. Result: It is a very beneficial area of research and its admittance in human therapy has given successful results clinically as well as therapeutically. Conclusion: The emphasis is carried on Benorylate, the Codrug of aspirin and paracetamol for improved anti-inflammatory and analgesic activity. The article also takes a review of the various applications of Codrugs and the development in this field during the last few decades.Export Options
About this article
Cite this article as:
Gangrade Deepali*, Karande Ravindra, Prodrugs to Codrugs, Current Drug Therapy 2017; 12 (1) . https://dx.doi.org/10.2174/1573413713666170210095211
DOI https://dx.doi.org/10.2174/1573413713666170210095211 |
Print ISSN 1574-8855 |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-3903 |
Call for Papers in Thematic Issues
Novel Therapeutic Approaches and Biomarkers for Chronic Kidney Disease (CKD)
The thematic issue on "Novel Therapeutic Approaches and Biomarkers for CKD" aims to provide a comprehensive exploration of cutting-edge strategies for the management of chronic kidney disease (CKD). This issue will delve into emerging therapeutic targets, focusing on critical aspects such as podocyte injury, endothelial dysfunction, and tubulointerstitial fibrosis, which ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Chalcones as Versatile Synthons for the Synthesis of 5- and 6-membered Nitrogen Heterocycles
Current Organic Chemistry A Review on CRISPR-mediated Epigenome Editing: A Future Directive for Therapeutic Management of Cancer
Current Drug Targets Population Based Helicobacter pylori Screening and Eradication: Advances Versus Side Effects
Current Pharmaceutical Design Mediterranean Diet and Oxidation: Nuts and Olive Oil as Important Sources of Fat and Antioxidants
Current Topics in Medicinal Chemistry Development and Pharmacological Evaluation of a PEG Based Nanoparticulate Camptothecin Analog for Oral Administration
Current Drug Delivery Diagnosis and Management of Endocrine Hypertension in Children and Adolescents
Current Pharmaceutical Design Anatomical, Biochemical and Physiological Considerations of the Colon in Design and Development of Novel Drug Delivery Systems
Current Drug Delivery Innovative Cancer Treatments that Augment Radiotherapy or Chemotherapy by the Use of Immunotherapy or Gene Therapy
Recent Patents on Anti-Cancer Drug Discovery Role of Nitric Oxide in Physiology and Pathology of the Gastrointestinal Tract
Mini-Reviews in Medicinal Chemistry Pseudogene PTENP1 Suppresses Gastric Cancer Progression by Modulating PTEN
Anti-Cancer Agents in Medicinal Chemistry Cytokines and Chemokines as Regulators of Angiogenesis in Health and Disease
Current Pharmaceutical Design Physical and Chemical Stimuli-Responsive Drug Delivery Systems: Targeted Delivery and Main Routes of Administration
Current Pharmaceutical Design Lipid Metabolism and Mitochondria: Cross Talk in Cancer
Current Drug Targets The Role of Oxidative Stress and Anti-Oxidant Treatment in Platinum- Induced Peripheral Neurotoxicity
Current Cancer Drug Targets Identification of Enzyme Inhibitors from Phage-Displayed Combinatorial Peptide Libraries
Combinatorial Chemistry & High Throughput Screening Functions of S100 Proteins
Current Molecular Medicine Molecular Mechanisms of Cardiac Voltage-Gated Potassium Channelopathies
Current Pharmaceutical Design Acute Effects of Neutrophil-Derived Oxidative Stress on Pulmonary Microvasculature
Current Respiratory Medicine Reviews Recent Advances of Metal Binding Protein Lactoferrin as an Anti- Microbial Agent
Current Bioactive Compounds MicroRNA-203: Tumor Suppression and Beyond
MicroRNA