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Combinatorial Chemistry & High Throughput Screening

Editor-in-Chief

ISSN (Print): 1386-2073
ISSN (Online): 1875-5402

Fluorescence Assays for High-Throughput Screening of Protein Kinases

Author(s): G. J.R. Zaman, A. Garritsen, Th. de Boer and C. A.A. van Boeckel

Volume 6, Issue 4, 2003

Page: [313 - 320] Pages: 8

DOI: 10.2174/138620703106298563

Price: $65

Abstract

Protein kinases comprise one of the most important group of targets for drug discovery research today. Methods to identify novel kinase inhibitors by high-throughput screening have evolved rapidly in recent years. An important aspect is the availability of fluorescent probes that can be applied in a homogeneous, or mix-and-measure, assay format. Here, we illustrate the application of fluorescence read-out technologies for kinase targets in light of our own experiences in assay development and high-throughput screening.

Keywords: fluorescence assays, high-throughput screening, protein kinases, novel kinase inhibitors


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