摘要
背景:癌症和阿尔茨海默氏病(AD)都与衰老有关,但并不经常发生在一起。肥胖是这两种疾病的共同危险因素,可能与这种奇怪的临床观察有关。脂肪细胞产生大量的活性物质,包括瘦素、脂联素;瘦素刺激和抑制癌症的广告性质,而脂联素可以抑制癌但刺激广告 目的:描述对癌症和瘦素和脂联素的反作用,勾勒出的信号转导通路参与这些影响并提出新的研究对疾病的有效控制策略。 方法:回顾性分析肿瘤/ AD的关系,以及过量脂肪作为共同危险因素的作用。先前的研究表明,p53、Wnt和其他细胞信号通路参与了这种逆关系。瘦素和脂联素对这些信号通路在癌症和AD中的对抗作用进行了评估。 结果:癌症/ AD之间的反向关系是有据可查的,过量的身体脂肪,特别是中心性肥胖的作用,增加了两种疾病的风险。瘦素和脂联素在肿瘤和AD中起着相反的作用,这些信号通过影响细胞凋亡、血管生成和其他细胞生长控制的信号传导因子。Wnt和p53在这些信号传导因子中很重要。 结论:瘦素和脂联素的特异性细胞信号通路介导的反作用与肿瘤/ AD的逆向关系有关。未来的研究旨在改变瘦素/脂联素比值可能导致癌症和AD的重要治疗和控制方法。
关键词: 癌症、阿尔茨海默病、瘦素、脂联素、脂肪因子、p53、Wnt
Current Alzheimer Research
Title:The Inverse Relationship Between Cancer and Alzheimer's Disease: A Possible Mechanism
Volume: 14 Issue: 8
关键词: 癌症、阿尔茨海默病、瘦素、脂联素、脂肪因子、p53、Wnt
摘要: Background: Cancer and Alzheimer's disease (AD) are both associated with aging, but do not often occur together. Obesity is a shared risk factor for both diseases and may be involved in this curious clinical observation. Fat cells produce many active substances, including leptin and adiponectin; leptin has cancer stimulating and AD inhibiting properties, while adiponectin can inhibit cancer but stimulate AD.
Objective: To describe the opposing effects of leptin and adiponectin on cancer and AD, to outline signaling pathways involved in these effects and to suggest new research on effective control strategies for both diseases. Methods: A review was conducted to document the inverse cancer/AD relationship and the role of excess body fat as a common risk factor. Previous studies have suggested the involvement of p53, Wnt and other cell signaling pathways in this inverse relationship. The opposing effects of leptin and adiponectin on these signaling pathways in cancer and AD were evaluated. Results: The inverse cancer/AD relationship is well documented, as is the role of excess body fat, especially central obesity, in increasing risk for both diseases. Leptin and adiponectin have opposing effects in cancer and AD mediated by signaling factors that influence apoptosis, angiogenesis, and other cell growth controls. Wnt and p53 are prominent among these signaling factors. Conclusion: Opposing effects of leptin and adiponectin, mediated by specific cell signaling pathways, are involved in the inverse cancer/Ad relationship. Future research aimed at modifying the leptin/adiponectin ratio may lead to important treatment and control approaches in both cancer and AD.Export Options
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Cite this article as:
The Inverse Relationship Between Cancer and Alzheimer's Disease: A Possible Mechanism, Current Alzheimer Research 2017; 14 (8) . https://dx.doi.org/10.2174/1567205014666170216152905
DOI https://dx.doi.org/10.2174/1567205014666170216152905 |
Print ISSN 1567-2050 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5828 |
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