Abstract
Hemocyanins are large and versatile glycoproteins performing various immunological and biological functions in many marine invertebrates including arthropods and molluscs. This review discusses the various pharmacological applications of mollusc hemocyanin such as antiviral activity, immunostimulatory and anticancer properties that have been reported in the literature between the years 2000 and 2016. Emphasis is placed on a better mechanistic understanding of hemocyanin as a therapeutic agent. Elucidation of the mechanism of action is essential to improve the clinical efficacy and for a better understanding of some endogenous immunological functions of this complex glycoprotein.
Keywords: Hemocyanin, mollusc, mechanism of action, antiviral activity, immunotherapy, cancer vaccines.
Current Medicinal Chemistry
Title:From Ocean to Bedside: the Therapeutic Potential of Molluscan Hemocyanins
Volume: 25 Issue: 20
Author(s): Negar Talaei Zanjani, Monica Miranda Saksena, Fariba Dehghani*Anthony L. Cunningham *
Affiliation:
- School of Chemical and Biomolecular Engineering, Faculty of Engineering & IT, The University of Sydney, Sydney,Australia
- Centre for Virus Research, Westmead Institute for Medical Research, The University of Sydney, Sydney,Australia
Keywords: Hemocyanin, mollusc, mechanism of action, antiviral activity, immunotherapy, cancer vaccines.
Abstract: Hemocyanins are large and versatile glycoproteins performing various immunological and biological functions in many marine invertebrates including arthropods and molluscs. This review discusses the various pharmacological applications of mollusc hemocyanin such as antiviral activity, immunostimulatory and anticancer properties that have been reported in the literature between the years 2000 and 2016. Emphasis is placed on a better mechanistic understanding of hemocyanin as a therapeutic agent. Elucidation of the mechanism of action is essential to improve the clinical efficacy and for a better understanding of some endogenous immunological functions of this complex glycoprotein.
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Cite this article as:
Zanjani Talaei Negar , Saksena Miranda Monica, Dehghani Fariba *, Cunningham L. Anthony *, From Ocean to Bedside: the Therapeutic Potential of Molluscan Hemocyanins, Current Medicinal Chemistry 2018; 25 (20) . https://dx.doi.org/10.2174/0929867324666170502124227
DOI https://dx.doi.org/10.2174/0929867324666170502124227 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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