摘要
背景:癌症是一个重大的全球健康问题。它给个人造成了巨大的痛苦,给社会的医疗带来了巨大的负担。尽管进行了广泛的研究,不同的工具也有b。即使发展起来,它仍然是早期发现这种疾病的一个挑战。FTIR成像技术已被用于诊断和鉴别正常组织和疾病组织之间的分子差异。 方法:傅里叶变换红外光谱法(FTIR)能够根据组织、细胞和生物液体的振动特征,测定其组织、细胞和生物液中的生化变化。这种技术LES对脂类、蛋白质、核酸以及其他代谢产物的分布和结构。这些差异取决于癌症的类型和分级。 结果:我们在此强调,FTIR光谱和成像技术可以被认为是一种很有前途的技术,并将因其敏感性高而被用于检测这种可怕的疾病。高精度,低成本的技术。现在医学界开始使用和接受这种技术来早期癌症检测。我们讨论了这种技术,以及我所面临的几个挑战它在样品制备、数据解释和数据分析等方面在癌症诊断中的应用。并讨论了化疗药物对个体特异性的敏感性。. 结论:红外成像技术在肿瘤病理研究中取得了一定的进展。然而,在这一领域还需要更多的研究,在使用光谱和成像之前,必须了解样品的形态和生物学,因为这是非常宝贵的计算出来的信息。
关键词: 红外成像,癌症,诊断,治疗药物,FTIR。
Current Medicinal Chemistry
Title:Role of Infrared Spectroscopy and Imaging in Cancer Diagnosis
Volume: 25 Issue: 9
关键词: 红外成像,癌症,诊断,治疗药物,FTIR。
摘要: Background: Cancer is a major global health issue. It causes extensive individual suffering and gives a huge burden on the health care in society. Despite extensive research and different tools have been developed it still remains a challenge for early detection of this disease. FTIR imaging has been used to diagnose and differentiate the molecular differences between normal and diseased tissues.
Methods: Fourier Transform Infrared Spectroscopy (FTIR) is able to measure biochemical changes in tissue, cell and biofluids based on the vibrational signature of their components. This technique enables to the distribution and structure of lipids, proteins, nucleic acids as well as other metabolites. These differences depended on the type and the grade of cancer.
Results: We emphasize here, that the FTIR spectroscopy and imaging can be considered as a promising technique and will find its place on the detection of this dreadful disease because of high sensitivity, accuracy and inexpensive technique. Now the medical community started using and accepting this technique for early stage cancer detection. We discussed this technique and the several challenges in its application for the diagnosis of cancer in regards of sample preparations, data interpretation, and data analysis. The sensitivity of chemotherapy drugs on individual specific has also discussed.
Conclusion: So far progressed has done with the FTIR imaging in understanding of cancer disease pathology. However, more research is needed in this field and it is necessary to understand the morphology and biology of the sample before using the spectroscopy and imaging because invaluable information to be figured out.
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Cite this article as:
Role of Infrared Spectroscopy and Imaging in Cancer Diagnosis, Current Medicinal Chemistry 2018; 25 (9) . https://dx.doi.org/10.2174/0929867324666170523121314
DOI https://dx.doi.org/10.2174/0929867324666170523121314 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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